视网膜厚度分析仪的偏心率、测量变异性和可重复性。
Eccentricity and measurement variability and repeatability with the retinal thickness analyser.
作者信息
Gilmore E D, Hudson C
机构信息
Department of Ophthalmology and Vision Science, Toronto Western Hospital, University of Toronto, Toronto, M5T 2S8 Ontario, Canada.
出版信息
Br J Ophthalmol. 2004 Jan;88(1):62-5. doi: 10.1136/bjo.88.1.62.
AIMS
To define the variability and repeatability of retinal thickness measurements using the retinal thickness analyser (RTA) and to elucidate any interaction between eccentricity (that is, position relative to the fovea) and variability and repeatability.
METHODS
The sample comprised 20 normal subjects of mean age 33 years. Each subject attended for two visits. Repeated RTA scans were acquired centred on the fovea and for any one of the four possible non-foveal scan areas. The mean retinal thickness (+SD) was calculated for a series of concentric circular bands centred on fixation. A repeated measures analysis of variance (ANOVA) was used to determine any significant interaction between the variability of RTA thickness values and eccentricity.
RESULTS
The group mean coefficient of variation and coefficient of repeatability were highest at the fovea. The repeated measures ANOVA revealed that the within test variability of RTA measurements varied significantly with eccentricity (p<0.0001). Similarly, the between test repeatability varied significantly with eccentricity (p = 0.045).
CONCLUSION
The significantly elevated within test variability and between test repeatability in the foveal area need to be considered when using the RTA to evaluate patients with macular disease.
目的
使用视网膜厚度分析仪（RTA）定义视网膜厚度测量的变异性和可重复性，并阐明偏心度（即相对于中央凹的位置）与变异性和可重复性之间的任何相互作用。
方法
样本包括20名平均年龄33岁的正常受试者。每位受试者进行两次就诊。以中央凹为中心以及在四个可能的非中央凹扫描区域中的任何一个区域进行重复的RTA扫描。计算以注视点为中心的一系列同心圆环带的平均视网膜厚度（±标准差）。使用重复测量方差分析（ANOVA）来确定RTA厚度值的变异性与偏心度之间的任何显著相互作用。
结果
中央凹处的组平均变异系数和重复系数最高。重复测量方差分析显示，RTA测量的测试内变异性随偏心度有显著变化（p<0.0001）。同样，测试间的可重复性也随偏心度有显著变化（p = 0.045）。
结论
在使用RTA评估黄斑疾病患者时，需要考虑中央凹区域测试内变异性和测试间可重复性显著升高的情况。
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