Crapanzano John P
Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Diagn Cytopathol. 2004 Jan;30(1):31-8. doi: 10.1002/dc.10417.
Low-grade endocrine neoplasms (LGENs) involving the liver usually show typical endocrine features. Occasionally these tumors display cytologic characteristics that mimic hepatocellular carcinoma (HCC) or adenocarcinoma (ACA). Twenty-four liver FNABs from 22 patients were reviewed. Twenty specimens showed cytologic characteristics typical of LGENs, including small to medium-sized cells with salt-and-pepper or granular chromatin, moderate to high N/C ratios, and inconspicuous or absent nucleoli. Plasmacytoid cells were observed in 19 cases. Immunocytochemical stains (ICCs) confirmed endocrine differentiation in 9 cases. 4 FNABs were comprised of larger tumor cells that displayed cytologic features that overlapped with HCC or ACA, including transgressing or wrapping endothelium, moderate to abundant cytoplasm, and conspicuous nucleoli. LGENs involving the liver typically demonstrate characteristic cytologic features. Cases comprised of larger cells with abundant cytoplasm, conspicuous nucleoli, and transgressing or wrapping endothelium may pose diagnostic difficulties. ICCs and plasmacytoid morphology are beneficial in classifying the endocrine origin of these tumors.
累及肝脏的低级别内分泌肿瘤（LGENs）通常表现出典型的内分泌特征。偶尔，这些肿瘤会呈现出类似肝细胞癌（HCC）或腺癌（ACA）的细胞学特征。回顾了22例患者的24份肝脏细针穿刺抽吸活检（FNAB）样本。20份样本表现出LGENs的典型细胞学特征，包括细胞核染色质呈椒盐状或颗粒状的中小细胞、中等至高核质比以及不明显或无核仁。19例观察到浆细胞样细胞。免疫细胞化学染色（ICCs）证实9例存在内分泌分化。4份FNAB样本由较大的肿瘤细胞组成，这些细胞表现出与HCC或ACA重叠的细胞学特征，包括侵犯或包裹内皮、中等至丰富的细胞质以及明显的核仁。累及肝脏的LGENs通常表现出特征性的细胞学特征。由具有丰富细胞质、明显核仁以及侵犯或包裹内皮的较大细胞组成的病例可能会造成诊断困难。ICCs和浆细胞样形态有助于对这些肿瘤的内分泌起源进行分类。
