Matsuda H, Nakamura S, Tanaka T, Kubo M
Faculty of Pharmaceutical Sciences, Kinki University, Osaka, Japan.
Yakugaku Zasshi. 1992 Sep;112(9):673-7. doi: 10.1248/yakushi1947.112.9_673.
Effects of water extract (UW-ext) from the leaf of Arctostaphylos uva-ursi (L.) Spreng (Bearberry leaf) on the antiallergic and antiinflammatory activities of dexamethasone ointment were investigated. One or 2% UW-ext ointment did not inhibit the ear swelling by picryl chloride-induced contact dermatitis (PC-CD) and carrageenin-induced paw edema. UW-ext augmented the inhibitory effect of dexamethasone ointment (0.005 or 0.025%) on these allergic and inflammatory models, but not the side effect of it. These results suggest that Bearberry leaf increases the inhibitory effect of dexamethasone on the allergic and inflammatory models.
研究了熊果叶（Arctostaphylos uva-ursi (L.) Spreng）水提取物（UW-ext）对地塞米松软膏抗过敏和抗炎活性的影响。1%或2%的UW-ext软膏对苦味酸诱导的接触性皮炎（PC-CD）和角叉菜胶诱导的爪肿胀没有抑制作用。UW-ext增强了地塞米松软膏（0.005%或0.025%）对这些过敏和炎症模型的抑制作用，但没有增强其副作用。这些结果表明，熊果叶增强了地塞米松对过敏和炎症模型的抑制作用。
