Matsuda H, Tanaka T, Kubo M
Faculty of Pharmaceutical Sciences, Kinki University, Osaka, Japan.
Yakugaku Zasshi. 1991 Apr-May;111(4-5):253-8. doi: 10.1248/yakushi1947.111.4-5_253.
A study was carried out to examine the combined effect of arbutin isolated from the leaves of Arctostaphylos uva-ursi (L.) Spreng. (Bearberry leaf) and indomethacin on Type IV allergic reaction-induced immuno-inflammation, carrageenin-induced edema and adjuvant-induced arthritis. Contact dermatitis caused by picryl chloride (PC-CD) and sheep red cell delayed type hypersensitivity (SRBC-DTH) was not inhibited by the oral application of arbutin at 2 divided doses immediately before and 16 h after the application, but arbutin at dose of 50 mg/kg 24 h after the application rapidly decreased the swelling of PC-CD. Arbutin (p.o.) plus indomethacin (s.c.) showed inhibitory effect on the swelling of PC-CD and SRBC-DTH stronger than that of indomethacin alone. When arbutin (p.o.) and indomethacin (s.c.) in a given portion were simultaneously administered, the inhibitory effect was more potent than that of indomethacin alone in both carrageenin-induced edema and adjuvant-induced arthritis. These results suggest that arbutin may increase the inhibitory action of indomethacin on PC-CD, SRBC-DTH, carrageenin-induced edema and adjuvant-induced arthritis, but further investigations are required to understand the mechanism involved.
开展了一项研究，以考察从熊果叶（Arctostaphylos uva-ursi (L.) Spreng.）中分离得到的熊果苷与吲哚美辛对IV型过敏反应诱导的免疫炎症、角叉菜胶诱导的水肿以及佐剂诱导的关节炎的联合作用。在使用苦味酸氯（PC-CD）引起的接触性皮炎和绵羊红细胞迟发型超敏反应（SRBC-DTH）中，在使用前立即和使用后16小时分两次口服熊果苷均未抑制上述反应，但在使用后24小时给予50mg/kg剂量的熊果苷能迅速减轻PC-CD的肿胀。口服熊果苷加皮下注射吲哚美辛对PC-CD和SRBC-DTH肿胀的抑制作用比单独使用吲哚美辛更强。当同时给予一定剂量的口服熊果苷和皮下注射吲哚美辛时，在角叉菜胶诱导的水肿和佐剂诱导的关节炎中，其抑制作用比单独使用吲哚美辛更有效。这些结果表明，熊果苷可能增强吲哚美辛对PC-CD、SRBC-DTH、角叉菜胶诱导的水肿和佐剂诱导的关节炎的抑制作用，但需要进一步研究以了解其中涉及的机制。
