Molinero Marco R, Varon Daniel, Holden Kenton R, Sladky John T, Molina Ida B, Cleaves Francisco
Department of Pediatric Neurology, Hospital Escuela Materno-Infantil, Tegucigalpa, Honduras, Central America.
J Child Neurol. 2003 Nov;18(11):741-7. doi: 10.1177/08830738030180110801.
The objective of this study was to investigate the incidence of acute flaccid paralysis in the pediatric population of Honduras over an 11-year period, determine what percentage of acute flaccid paralysis was Guillain-Barré syndrome, and identify the epidemiologic features of Guillain-Barré syndrome. There were 546 childhood cases of acute flaccid paralysis seen between January 1989 and December 1999 at the Hospital Escuela Materno-Infantil in Tegucigalpa, Honduras. Of these cases with acute flaccid paralysis, 394 (72.2%) were diagnosed with Guillain-Barré syndrome. Our incidence of Guillain-Barré syndrome in the Honduran pediatric population (1.37/100,000 per year) is higher than that shown in other studies. There was a significantly higher incidence of Guillain-Barré syndrome in younger children (ages 1-4 years), a significant preponderance of cases from rural areas, and a mild predominance in boys but a typical clinical presentation. The Honduran pediatric Guillain-Barré syndrome population had an increased mortality rate. Guillain-Barré syndrome has become the leading cause of childhood paralysis in Honduras. A better understanding of the population at highest risk and opportunities for earlier intervention with more effective therapeutic modalities may permit reducing the mortality among Honduran children who develop Guillain-Barré syndrome.
本研究的目的是调查洪都拉斯11年间儿科人群中急性弛缓性麻痹的发病率，确定急性弛缓性麻痹中格林-巴利综合征所占的百分比，并确定格林-巴利综合征的流行病学特征。1989年1月至1999年12月期间，在洪都拉斯特古西加尔巴的母婴儿童医院共发现546例儿童急性弛缓性麻痹病例。在这些急性弛缓性麻痹病例中，394例（72.2%）被诊断为格林-巴利综合征。我们所发现的洪都拉斯儿科人群中格林-巴利综合征的发病率（每年1.37/10万）高于其他研究报道。年龄较小的儿童（1至4岁）格林-巴利综合征的发病率显著更高，农村地区的病例明显占多数，男性略占优势，但临床表现典型。洪都拉斯患格林-巴利综合征的儿科人群死亡率有所上升。格林-巴利综合征已成为洪都拉斯儿童瘫痪的主要原因。更好地了解高危人群以及采用更有效的治疗方式进行早期干预的机会，可能有助于降低患格林-巴利综合征的洪都拉斯儿童的死亡率。
