从牛膝草（神香草）中分离α-葡萄糖苷酶抑制剂。
Isolation of alpha-glusosidase inhibitors from hyssop (Hyssopus officinalis).
作者信息
Matsuura Hideyuki, Miyazaki Hiroyuki, Asakawa Chikako, Amano Midori, Yoshihara Teruhiko, Mizutani Junya
机构信息
Northern Advancement Center for Science and Technology, Kita-21, Nishi-12, Sapporo, Hokkaido, 001-0021, Japan.
出版信息
Phytochemistry. 2004 Jan;65(1):91-7. doi: 10.1016/j.phytochem.2003.10.009.
alpha-Glucosidase inhibitory activity was found in aqueous methanol extracts of dried hyssop (Hyssopus officinalis) leaves. Active principles against alpha-glucosidase, prepared from rat small intestine acetone powders, were isolated and characterized. The structures of these isolated compounds were determined to be (7S, 8S)-syringoylglycerol-9-O-(6'-O-cinnamoyl)-beta-D-glucopyranoside and (7S, 8S)-syringoylglycerol 9-O-beta-D-glucopyranoside by analysis of physical and spectroscopic data (FDMS, 1H NMR, 13C NMR, HMQC, and HMBC experiments) together with chemical syntheses.
在干燥的牛膝草（神香草）叶片的甲醇水提取物中发现了α-葡萄糖苷酶抑制活性。从大鼠小肠丙酮粉中制备了针对α-葡萄糖苷酶的活性成分，并对其进行了分离和表征。通过物理和光谱数据（场解吸质谱、1H核磁共振、13C核磁共振、异核多量子相干和异核多键相关实验）分析以及化学合成，确定这些分离化合物的结构为(7S, 8S)-丁香酰甘油-9-O-(6'-O-肉桂酰基)-β-D-吡喃葡萄糖苷和(7S, 8S)-丁香酰甘油9-O-β-D-吡喃葡萄糖苷。
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