Riederer Peter, Danielczyk Walter, Grünblatt Edna
Neurochemical Laboratory, Clinic for Psychiatry and Psychotherapy, Bayerische Julius-Maximilians-Universität Würzburg, Füchsleinstr 15, 97080 Würzburg, Germany.
Neurotoxicology. 2004 Jan;25(1-2):271-7. doi: 10.1016/S0161-813X(03)00106-2.
Alzheimer's disease (AD) is the most common cause of dementia in late life. There is still no clear-cut consensus whether this disease involves genetic or environmental factors or both. There is a great need to find a way to delay the disease, as delaying the onset of the disease will bring a great relieve on social and medical resources. The monoamine oxidase-B (MAO-B) inhibitors were shown to be effective in treating Parkinson's disease and possibly AD, with concomitant extension of life span. This article gives a short review on MAO-B inhibitors and their mechanism for neuroprotective effects in AD.
阿尔茨海默病（AD）是晚年痴呆最常见的病因。关于这种疾病是涉及遗传因素还是环境因素，抑或是两者皆有，目前仍没有明确的共识。迫切需要找到一种延缓该病的方法，因为延缓疾病的发作将极大减轻社会和医疗资源的负担。单胺氧化酶-B（MAO-B）抑制剂已被证明对治疗帕金森病有效，对AD可能也有效，同时还能延长寿命。本文简要综述了MAO-B抑制剂及其在AD中的神经保护作用机制。
