Effects of fluorine substitution of cytosine analogues on the binding affinity to HIV-1 reverse transcriptase.
作者信息
Chong Youhoon, Choo Hyunah, Chu Chung K
机构信息
Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens, GA 30602, USA.
出版信息
Bioorg Med Chem Lett. 2004 Jan 19;14(2):437-40. doi: 10.1016/j.bmcl.2003.10.042.
PMID:14698176
Abstract
In order to find out the possible role of fluorine substituent in binding of the fluorinated cytidine analogues at the active site of HIV-1 RT, binding modes of several 5-fluoro cytidine analogues, such as FTC, D-dioxolane 5-FC and D-2'F-d4FC to the active site of HIV-1 reverse transcriptase, were compared by molecular dynamics studies.
摘要
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