胞壁酰二肽/3-脱氧-D-甘露糖庚酮糖合成酶抑制剂与抗菌剂对肠出血性大肠杆菌O157:H7产生和释放维罗毒素的抑制协同作用。
Synergistic effect of CMP/KDO synthase inhibitors with antimicrobial agents on inhibition of production and release of Vero toxin by enterohaemorrhagic Escherichia coli O157:H7.
作者信息
Kondo Ken-ichiro, Doi Hiroyasu, Adachi Hayamitsu, Nishimura Yoshio
机构信息
Microbial Chemistry Research Center, 3-14-23 Kamiosaki, Shinagawa-ku, 141-0021, Tokyo, Japan.
出版信息
Bioorg Med Chem Lett. 2004 Jan 19;14(2):467-70. doi: 10.1016/j.bmcl.2003.10.046.
Synergistic effect of CMP/KDO synthase inhibitors in LPS biosynthesis of Gram-negative bacteria with kanamycin (KM) and fosfomycin (FOM) on the production and release of Vero toxins (VTs) by Escherichia coli O157 was evaluated in vitro. While CMP/KDO synthase inhibitors, KM and FOM showed no inhibitory effect on the production/release of VTs by themselves alone, both KM and FOM showed the remarkable inhibition of VT2 release through synergistic collaboration with CMP:KDO synthase inhibitor.
在体外评估了胞苷一磷酸/3-脱氧-D-甘露-2-辛酮糖酸（CMP/KDO）合酶抑制剂与卡那霉素（KM）和磷霉素（FOM）联合作用对革兰氏阴性菌脂多糖（LPS）生物合成以及大肠杆菌O157产生和释放志贺毒素（VTs）的协同效应。虽然CMP/KDO合酶抑制剂、KM和FOM单独使用时对VTs的产生/释放均无抑制作用，但KM和FOM与CMP/KDO合酶抑制剂协同作用时均显著抑制了VT2的释放。
Zotero 插件