Shun-xing Li, Nan-sheng Deng, Feng-ying Zheng
Zhangzhou Teachers College, 363000, PR, Zhangzhou, China.
Bioorg Med Chem Lett. 2004 Jan 19;14(2):505-10. doi: 10.1016/j.bmcl.2003.10.034.
The effects of compatibility, that is combination of Prunus persica Batsch (L.) and Carthamus tinctorus (L.), and different acidity of digestive site on the species, lipopily and bioavailability of coordinated complex of iron, manganese, and zinc in medical decoction were studied. In view of octanol, a long-chain alkanol, resembled as the configuration of carbohydrate and adipose in human body, the octanol- and water-solubility were used to define the species of trace element in phytomedicine, to identify the lipopily and bioavailability of trace element, and octanol-water system was adopted to study the distribution of trace element in decoction of P. persica Batsch (L.) (A), C. tinctorus (L.) (B), and combination of medicine A and B (C) in stomach and intestine. The total concentration, water- and octanol-solubility concentration of iron, manganese, and zinc in medicinal material A, B and C or its decoction under gastric and intestinal acidity, were determined respectively by flame atomic absorption spectrometry, analyzed and compared. The compatibility of medicine A and B enhances the extract percent, octanol-solubility concentration, and stability of coordinated complex of iron, manganese, and zinc. Different acidity of digestive site and compatibility of medicines impact on the ligands of iron, manganese, and zinc, then greatly affect the species and its quantification, the lipopily and bioavailability of trace element. Such influence is quite different for different trace element. Such factors, especially the concentration of octanol-solubility trace element, could be the basis of the dosage to avoid trace element overload.
研究了桃仁（Prunus persica Batsch (L.)）与红花（Carthamus tinctorus (L.)）配伍以及消化部位不同酸度对药汤中铁、锰、锌配位络合物的种类、脂溶性和生物利用度的影响。鉴于长链烷醇正辛醇类似于人体中碳水化合物和脂肪的构型，采用正辛醇 - 水溶解性来确定植物药中微量元素的种类，鉴定微量元素的脂溶性和生物利用度，并采用正辛醇 - 水体系研究微量元素在桃仁（A）、红花（B）及其配伍（C）药汤在胃和肠道中的分布。分别用火焰原子吸收光谱法测定药材A、B、C及其药汤在胃肠酸度条件下铁、锰、锌的总浓度、水溶性浓度和正辛醇溶性浓度，并进行分析比较。药物A与B的配伍提高了铁、锰、锌配位络合物的提取率、正辛醇溶性浓度和稳定性。消化部位的不同酸度和药物配伍影响铁、锰、锌的配体情况，进而极大地影响微量元素的种类及其定量、脂溶性和生物利用度。不同微量元素受到的这种影响差异很大。这些因素，尤其是正辛醇溶性微量元素的浓度，可作为避免微量元素过量的用药剂量依据。
