Yasuda Masahiro, Fujino Motoko, Nasu Tetsuo, Murakami Takayuki
Department of Veterinary Anatomy, Faculty of Agriculture, Miyazaki University, 1-1 Kibanadai-nishi, 889-2192, Miyazaki, Japan
Dev Comp Immunol. 2004 Apr;28(4):357-69. doi: 10.1016/j.dci.2003.09.013.
The development and distribution of lymphocyte subsets in bovine gut-associated lymphoid tissues (ileal and jejunal Peyer's patches (PP)) were examined. Before birth, the composition of lymphocyte subsets in both PP follicles did not differ except for the dimensions of the interfollicular area and the dome region. Many IgM+ cells were observed in these follicles, but very few CD3+, IgG+, and IgA+ cells could be found. At neonatal period, the IgG+ cells, which did not produce IgG mRNA, were dominant within both PP follicles. From 1 month after birth, many CD3+ cells, IgG mRNA expression, and IgA mRNA expression were detected within the jejunal PP follicles, but very few were in the ileal PP follicles. These data suggest that the characteristics of the jejunal PP follicles metamorphose into secondary lymphoid tissue such as germinal centers at around 1 month after birth, whereas the characteristics of ileal PP follicles were distinct from those of germinal centers.
研究了牛肠道相关淋巴组织（回肠和空肠派伊尔结（PP））中淋巴细胞亚群的发育和分布。出生前，两个PP滤泡中淋巴细胞亚群的组成除滤泡间区域和圆顶区域的大小外没有差异。在这些滤泡中观察到许多IgM+细胞，但能发现的CD3+、IgG+和IgA+细胞很少。在新生儿期，不产生IgG mRNA的IgG+细胞在两个PP滤泡中占主导地位。出生后1个月起，在空肠PP滤泡中检测到许多CD3+细胞、IgG mRNA表达和IgA mRNA表达，但在回肠PP滤泡中很少。这些数据表明，空肠PP滤泡的特征在出生后约1个月时转变为二级淋巴组织，如生发中心，而回肠PP滤泡的特征与生发中心不同。
