Blandin Stéphanie, Levashina Elena A
European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany.
Mol Immunol. 2004 Feb;40(12):903-8. doi: 10.1016/j.molimm.2003.10.010.
Here, we discuss the role of thioester-containing proteins in innate immune responses of insects. TEPs are represented by multi-member families both in the fruitfly, Drosophila melanogaster, and in the mosquito, Anopheles gambiae. Phylogenetic analysis of the family suggests that in these two dipteran species evolution of TEPs followed independent scenarios as a result of specific adaptation to distinct ecological environments. Research on these two relatively simple model systems, which lack adaptive immunity, may provide new insights into the evolutionary origins and functions of this important protein family.
在此，我们讨论含硫酯蛋白在昆虫先天免疫反应中的作用。硫酯蛋白在果蝇（黑腹果蝇）和蚊子（冈比亚按蚊）中均由多成员家族所代表。对该家族的系统发育分析表明，在这两种双翅目物种中，由于对不同生态环境的特定适应，硫酯蛋白的进化遵循了独立的模式。对这两个缺乏适应性免疫的相对简单的模型系统进行研究，可能会为这个重要蛋白家族的进化起源和功能提供新的见解。
