Vancheri Carlo, Mastruzzo Claudio, Sortino Maria Angela, Crimi Nunzio
Department of Internal and Specialistic Medicine, Section of Respiratory Diseases, University of Catania, Via Passo Gravina, 187, 95125, Catania, Italy.
Trends Immunol. 2004 Jan;25(1):40-6. doi: 10.1016/j.it.2003.11.001.
Prostaglandin E2 (PGE2) is commonly considered a potent proinflammatory mediator and is involved in several inflammatory diseases. In the lung, as opposed to many other parts of the body, PGE2 has a role in limiting the immune-inflammatory response as well as tissue repair processes. Understanding the full implications of the regulatory role of PGE2 and how beneficial processes, such as inflammation and tissue repair, become dysregulated to the point of causing disease, might disclose new perspectives in the treatment of pulmonary diseases.
前列腺素E2（PGE2）通常被认为是一种强效促炎介质，参与多种炎症性疾病。与身体的许多其他部位不同，在肺部，PGE2在限制免疫炎症反应以及组织修复过程中发挥作用。了解PGE2调节作用的全部影响，以及诸如炎症和组织修复等有益过程如何失调至引发疾病的程度，可能会揭示肺部疾病治疗的新视角。
