印楝叶提取物凝胶抗牙菌斑活性的评估——一项为期6周的临床研究。

Evaluation of antiplaque activity of Azadirachta indica leaf extract gel--a 6-week clinical study.

作者信息

Pai M Raveendra, Acharya Leelavathi D, Udupa N

机构信息

Department of Pharmaceutics, College of Pharmaceutical Sciences, Manipal Academy of Higher Education, 576119, Manipal, India

出版信息

J Ethnopharmacol. 2004 Jan;90(1):99-103. doi: 10.1016/j.jep.2003.09.035.

DOI:10.1016/j.jep.2003.09.035

PMID:14698516

Abstract

Various chemical agents have been evaluated over the years with respect to their antimicrobial effects in the oral cavity; however, all are associated with side effects that prohibit regular long-term use. Therefore, the effectiveness of neem (Azadirachta indica A. Juss) leaf extract against plaque formation was assessed in males between the age group of 20-30 years over a period of 6 weeks. Present study includes formulation of mucoadhesive dental gel containing Azadirachta indica leaf extract (25 mg/g). A 6-week clinical study was conducted to evaluate the efficacy of neem extract dental gel with commercially available chlorhexidine gluconate (0.2% w/v) mouthwash as positive control. Microbial evaluation of Streptococcus mutans and Lactobacilli species was carried out to determine the total decrease in the salivary bacterial count over a period of treatment using a semi-quantitative four quadrant streaking method. The results of the study suggested that the dental gel containing neem extract has significantly (P<0.05) reduced the plaque index and bacterial count than that of the control group.

摘要

多年来，人们对各种化学药剂在口腔中的抗菌效果进行了评估；然而，所有这些药剂都存在副作用，这使得它们无法长期定期使用。因此，研究人员在20至30岁的男性中评估了印楝（Azadirachta indica A. Juss）叶提取物对牙菌斑形成的抑制效果，研究为期6周。本研究包括含印楝叶提取物（25毫克/克）的黏膜黏附性牙科凝胶的配方。进行了一项为期6周的临床研究，以评估印楝提取物牙科凝胶的疗效，以市售葡萄糖酸洗必泰（0.2% w/v）漱口水作为阳性对照。采用半定量四象限划线法对变形链球菌和乳酸杆菌进行微生物评估，以确定治疗期间唾液细菌总数的减少情况。研究结果表明，含印楝提取物的牙科凝胶比对照组显著（P<0.05）降低了菌斑指数和细菌数量。