Parexel International India Pvt. Ltd., Mohali 140308, Punjab, India.
Department of Pharmaceutics, Rayat Bahra Institute of Pharmacy, Hoshiarpur 146104, Punjab, India.
Recent Pat Drug Deliv Formul. 2020;14(2):145-161. doi: 10.2174/1872211314666200820142509.
Dental caries originate due to the localized dissolution of the hard tissues of teeth, mainly caused by acids, developed by the presence of microorganisms in the biofilm (dental plaque) on the surface of teeth causing "cavities". Commercially available liquid mouthwashes containing synthetic active ingredients possess limitations like teeth staining, higher alcoholic content, taste disturbances, xerostomia, and stability issues.
To make the solid preparation for oral hygiene (US6428770B1) in the form of herbal effervescent mouthwash tablet (CN106619318A, US8728446B2) using Azadirachta indica and Curcumin having antimicrobial, antibacterial, antiplaque, and anti-inflammatory activity.
The optimization study of effervescent granules was performed by 33 factorial design. A total of 27 preliminary experimental batches were prepared by the fusion method, varying the amount of citric acid, tartaric acid, and sodium bicarbonate. A complex of curcumin was prepared with hydroxyl propyl β-cyclodextrin and further examined by scanning electron microscopy. The prepared tablets were evaluated for pre and post-compression parameters. The in vitro antimicrobial study was performed by Agar well diffusion method against S. mutans.
All the experimental batches of effervescent granules were evaluated for pH, effervescent time, and CO2 content. Six batches were further selected for final tablet preparation. The results of the pre-compression parameters revealed excellent flow properties and post-compression parameters; the results were also significant. The antimicrobial study revealed the F3 as a final best formulation.
The developed herbal formulation (F3) has a good potential to maintain oral hygiene as compared to alcoholic mouthwash and further studies may be necessary to confirm the efficacy of the formulation since only a single bacterial strain was assayed.
龋齿是由于牙齿硬组织的局部溶解引起的，主要由微生物在牙齿表面生物膜（牙菌斑）中产生的酸引起，导致“龋齿”。市售的含合成活性成分的液体漱口水存在牙齿染色、酒精含量高、口感干扰、口干和稳定性问题等局限性。
以具有抗菌、抑菌、抗菌斑和抗炎活性的印楝和姜黄素为原料，制成口腔卫生用固体制剂（US6428770B1），即草药泡腾口含片（CN106619318A，US8728446B2）。
采用 33 因子设计对泡腾颗粒进行优化研究。通过熔融法共制备 27 批预实验批次，改变柠檬酸、酒石酸和碳酸氢钠的用量。用羟丙基-β-环糊精制备姜黄素复合物，并进一步用扫描电子显微镜进行检查。对制备的片剂进行压片前和压片后的参数评价。采用琼脂孔扩散法对变形链球菌进行体外抗菌研究。
对所有泡腾颗粒的实验批次进行 pH 值、发泡时间和 CO2 含量评价。进一步选择 6 批进行最终片剂制备。预压参数的结果显示出良好的流动特性和抗压参数，结果也具有显著性。抗菌研究表明 F3 是最终的最佳配方。
与含酒精的漱口水相比，所开发的草药配方（F3）具有良好的口腔卫生维持潜力，由于仅检测了单一细菌株，因此可能需要进一步研究以确认配方的功效。
