叶酸受体作为肿瘤选择性放射性核素递送的分子靶点。
The folate receptor as a molecular target for tumor-selective radionuclide delivery.
作者信息
Ke Chun-Yen, Mathias Carla J, Green Mark A
机构信息
Department of Industrial and Physical Pharmacy, Purdue University, West, Lafayette, IN 47907-2091, USA.
出版信息
Nucl Med Biol. 2003 Nov;30(8):811-7. doi: 10.1016/s0969-8051(03)00117-3.
Abstract
The cell-membrane folate receptor is a potential molecular target for tumor-selective drug delivery, including radiolabeled folate-chelate conjugates for diagnostic imaging. We review here some background on the folate receptor as tumor-associated molecular target for drug delivery, and briefly survey the literature on tumor-targeting with radiolabeled folate-chelate conjugates.
摘要
细胞膜叶酸受体是肿瘤选择性药物递送的潜在分子靶点，包括用于诊断成像的放射性标记叶酸螯合物缀合物。在此，我们综述了叶酸受体作为肿瘤相关药物递送分子靶点的一些背景知识，并简要概述了有关放射性标记叶酸螯合物缀合物肿瘤靶向的文献。
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