来自尖刺松节藻（红藻科，仙菜目）的硫酸琼脂的结构及其抗病毒活性。琼脂中结构与抗病毒活性之间的关系。
The structure of the agaran sulfate from Acanthophora spicifera (Rhodomelaceae, Ceramiales) and its antiviral activity. Relation between structure and antiviral activity in agarans.
作者信息
Duarte Maria E R, Cauduro Jean P, Noseda Diego G, Noseda Miguel D, Gonçalves Alan G, Pujol Carlos A, Damonte Elsa B, Cerezo Alberto S
机构信息
Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Paraná, P.O. Box 19046, CEP 81531-990, Curitiba, Paraná, Brazil.
出版信息
Carbohydr Res. 2004 Jan 22;339(2):335-47. doi: 10.1016/j.carres.2003.09.028.
The sulfated agaran isolated by water extraction from the red seaweed, Acanthophora spicifera (Rhodomelaceae, Ceramiales), is made up of A-units highly substituted with sulfate groups on C-2 (28-30%), sulfates on C-2 and 4,6-O-(1'-carboxyethylidene) groups (9-15%), and only the C-2 sulfate groups (5-8%) with small amounts of C-6 sulfate, 6-O-methyl, and nonsubstituted residues. B-units are formed mainly by 3,6-anhydro-alpha-L-galactose (15-16%) and its precursor, alpha-L-galactose 6-sulfate (10-17%), together with lesser amounts of 3,6-anhydro-alpha-L-galactose 2-sulfate, alpha-L-galactose 2,6-disulfate, alpha-L-galactose 2,3,6-tri-sulfate, alpha-L-galactose 2,6-disulfate 3-xylose, 2-O-methyl-alpha-L-galactose, and unsubstituted alpha-L-galactose. Small, but significant quantities of beta-D-xylose were found in all the fractions, together with small amounts to traces of D-glucose. Some of the fractions have high antiviral activity. Attempts to correlate structure and antiviral activity in agarans are presented.
从红藻多刺顶孢藻（红翎菜科，仙菜目）中通过水提取法分离得到的硫酸化琼脂糖，由A单元组成，这些A单元在C-2位上高度硫酸化（28-30%），C-2位和4,6-O-(1'-羧基亚乙基)位有硫酸根（9-15%），只有C-2位硫酸根（5-8%），还有少量C-6位硫酸根、6-O-甲基和未取代的残基。B单元主要由3,6-脱水-α-L-半乳糖（15-16%）及其前体α-L-半乳糖6-硫酸酯（10-17%）组成，还有少量的3,6-脱水-α-L-半乳糖2-硫酸酯、α-L-半乳糖2,6-二硫酸酯、α-L-半乳糖2,3,6-三硫酸酯、α-L-半乳糖2,6-二硫酸酯3-木糖、2-O-甲基-α-L-半乳糖和未取代的α-L-半乳糖。在所有组分中都发现了少量但显著量的β-D-木糖，以及少量至痕量的D-葡萄糖。一些组分具有较高的抗病毒活性。文中介绍了对琼脂糖结构与抗病毒活性之间相关性的研究尝试。
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