MacArthur Rodger D, Miller Mark, Albertson Timothy, Panacek Edward, Johnson David, Teoh Leah, Barchuk William
Wayne State University, Detroit, Michigan 48201, USA.
Clin Infect Dis. 2004 Jan 15;38(2):284-8. doi: 10.1086/379825. Epub 2003 Dec 22.
As part of the Monoclonal Anti-TNF: A Randomized Controlled Sepsis (MONARCS) trial, which enrolled patients with suspected sepsis, we sought to determine whether adequate antibiotic therapy was associated with a decreased mortality rate. The study enrolled 2634 patients, 91% of whom received adequate antibiotic therapy. The mortality rate among patients given adequate antibiotic treatment was 33%, versus 43% among patients given inadequate treatment (P<.001). We conclude that adequate antibiotic therapy results in a significant decrease in the crude mortality rate among patients suspected of sepsis.
作为单克隆抗TNF：随机对照脓毒症（MONARCS）试验的一部分，该试验纳入了疑似脓毒症患者，我们试图确定充分的抗生素治疗是否与降低死亡率相关。该研究纳入了2634例患者，其中91%接受了充分的抗生素治疗。接受充分抗生素治疗的患者死亡率为33%，而治疗不充分的患者死亡率为43%（P<0.001）。我们得出结论，充分的抗生素治疗可使疑似脓毒症患者的粗死亡率显著降低。
