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小儿坏血病:28例病例回顾

Scurvy in pediatric patients: a review of 28 cases.

作者信息

Ratanachu-Ek Suntaree, Sukswai Pisit, Jeerathanyasakun Yongyot, Wongtapradit Lawan

机构信息

Department of Pediatrics, Queen Sirikit National Institute of Child Health, Bangkok 10400, Thailand.

出版信息

J Med Assoc Thai. 2003 Aug;86 Suppl 3:S734-40.

Abstract

OBJECTIVE

To study the dietary factors, clinical findings, plasma vitamin C level and post-treatment outcome of scurvy in pediatric patients at Queen Sirikit National Institute of Child Health.

STUDY DESIGN

A retrospective study.

METHOD

The medical and radiographic records of pediatric patients, diagnosed with scurvy at Queen Sirikit National Institute of Child Health from 1995 to 2002 were reviewed.

RESULTS

Twenty-eight pediatric patients were diagnosed with scurvy. Their ages ranged between 10 months-9 years 7 months (median age of 29 months). 93 per cent of the cases were between 1-4 years of age. All were fed with well-cooked foods and small amounts or no vegetables and fruits. Supplementation with ultra heat temperature (UHT) milk was found in 89 per cent, average 5.8 boxes/day and 14.3 months in duration. Eighty-six per cent of cases were misdiagnosed previously. Clinical manifestations involved limp or inability to walk (96%), tenderness of lower limbs (86%), bleeding per gum (36%), fever (18%), and petechial hemorrhage (3.6%). All cases had abnormal radiographic findings compatible with scurvy and 2 cases had epiphyseal separation. All had clinical improvement within the first week after vitamin C supplementation.

CONCLUSION

Vitamin C deficiency was found in the children's intake of small amounts or no vegetables and fruits together with UHT-milk. Frequent manifestations were limping and inability to walk and pain in the lower limbs. Response to vitamin C treatment was dramatic.

摘要

目的

研究诗丽吉王后国家儿童健康研究所儿科坏血病患者的饮食因素、临床表现、血浆维生素C水平及治疗后结果。

研究设计

一项回顾性研究。

方法

回顾了1995年至2002年在诗丽吉王后国家儿童健康研究所被诊断为坏血病的儿科患者的医疗和影像学记录。

结果

28例儿科患者被诊断为坏血病。他们的年龄在10个月至9岁7个月之间(中位年龄为29个月)。93%的病例年龄在1至4岁之间。所有患者均食用精心烹饪的食物,很少或不食用蔬菜和水果。89%的患者补充了超高温灭菌(UHT)牛奶,平均每天5.8盒,持续14.3个月。86%的病例之前被误诊。临床表现包括跛行或无法行走(96%)、下肢压痛(86%)、牙龈出血(36%)、发热(18%)和瘀点出血(3.6%)。所有病例的影像学检查结果均与坏血病相符,2例有骨骺分离。补充维生素C后的第一周内所有患者的临床症状均有改善。

结论

儿童因摄入少量或不摄入蔬菜和水果以及饮用超高温灭菌牛奶而出现维生素C缺乏。常见表现为跛行、无法行走和下肢疼痛。对维生素C治疗反应显著。

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