Xu Jie, Yang Min, Liu Zhuang
Department of Infectious Diseases, Ditan Hospital, Beijing 100011, China.
Zhonghua Jie He He Hu Xi Za Zhi. 2003 Nov;26(11):683-5.
To study the epidemiological, clinical and laboratory characteristics, treatment and prognosis of patients with severe acute respiratory syndrome (SARS).
Clinical data from 250 patients with SARS were retrospectively analyzed.
The age of the patients were 36 +/- 16, 44.0% (n = 110) were male, and 56.0% (n = 140) were female. The incubation period was 8 +/- 7 days. The most common symptom were fever (100. 0%), cough (72.8%), and fatigue (70.0%). 27.2% of the patients had decreased white blood cell counts. 64.2% of the patients had decreased lymphocytes. 91.4% and 80.6% of the patients had decreased CD(4)(+) and CD(8)(+) cell counts, respectively. 162 patients (64.8%) had decreased SaO(2). Serum ALT, AST, LDH and CK were elevated in 45.2%, 29.4%, 42.1%, and 18.3% of the patients respectively. Serum IgG to SARS virus was positive in 69.9% of the patients at recovery stage. General combination therapy including antibiotics, anti-viral agents, glucocorticoids and immunity-enhancing agents, was used. Artificial ventilation was used in 196 patients including 8 for whom invasive mechanical ventilation was used Eighty-one (32.4%) were diagnosed as having severe type of SARS. 25 patients died of SARS.
SARS is a highly communicable disease and mostly affects youth and people in their prime of life. It has characteristic clinical manifestations. Combination therapy can be very effective for most patients.
研究重症急性呼吸综合征（SARS）患者的流行病学、临床及实验室特征、治疗方法及预后。
对250例SARS患者的临床资料进行回顾性分析。
患者年龄为36±16岁，男性占44.0%（n = 110），女性占56.0%（n = 140）。潜伏期为8±7天。最常见的症状为发热（100.0%）、咳嗽（72.8%）和乏力（70.0%）。27.2%的患者白细胞计数降低。64.2%的患者淋巴细胞减少。91.4%和80.6%的患者CD4(+)和CD8(+)细胞计数分别降低。162例患者（64.8%）动脉血氧饱和度（SaO2）降低。分别有45.2%、29.4%、42.1%和18.3%的患者血清谷丙转氨酶（ALT）、谷草转氨酶（AST）、乳酸脱氢酶（LDH）和肌酸激酶（CK）升高。恢复期69.9%的患者血清抗SARS病毒IgG呈阳性。采用包括抗生素、抗病毒药物、糖皮质激素和免疫增强剂在内的综合治疗方法。196例患者使用了人工通气，其中8例使用有创机械通气。81例（32.4%）被诊断为重症SARS。25例患者死于SARS。
SARS是一种高度传染性疾病，主要影响青年人和青壮年。它具有特征性的临床表现。综合治疗对大多数患者可能非常有效。
