Gewirtzman G B, Winkler N W, Dobson R L
Arch Dermatol. 1978 Feb;114(2):259-61.
Erythrokeratodermia variabilis is a rare genodermatosis; American authors have reported only four previous cases. It had been a problem to obtain a large pedigree for clinical investigation. We studied a family with 12 involved members in five generations. Symmetrically distributed migratory patches and scaling plaques are characteristic and were found to involute with a combination of keratolytic agents and topical steroids. Exacerbations of these patches and plaques were noted in our female patients during such high estrogen states as pregnancy or oral contraceptive usage.
可变型红斑角皮病是一种罕见的遗传性皮肤病；美国作者此前仅报道过4例。获取用于临床研究的大型家系一直是个难题。我们研究了一个五代中有12名受累成员的家族。对称分布的游走性斑块和鳞屑性斑片是其特征性表现，发现联合使用角质松解剂和外用类固醇可使其消退。在我们的女性患者中，在妊娠或使用口服避孕药等高雌激素状态期间，这些斑块和斑片会加重。
