血管成形术及支架置入术治疗重度颈内动脉狭窄：39例入选患者的安全性研究
Angioplasty and stenting for high-grade internal carotid artery stenosis: safety study in 39 selected patients.
作者信息
Debette S, Hénon H, Gauvrit J Y, Haulon S, Mackowiak-Cordoliani M A, Gautier C, Deplanque D, Lucas C, Leclerc X, Koussa M, Pruvo J P, Leys D
机构信息
Department of Neurology (EA 2691), Lille University Hospital, France.
出版信息
Cerebrovasc Dis. 2004;17(2-3):160-5. doi: 10.1159/000075785. Epub 2003 Dec 23.
BACKGROUND
Carotid angioplasty and stenting (CAS) is sometimes used as an alternative to surgery, despite the lack of evidence for its safety and efficacy.
METHOD
Over a 33-month period, 39 consecutive patients with a stenosis >/=70% underwent CAS (4 in a randomized trial and 35 because of contra-indications for surgery).
RESULTS
In 5 patients (13%; 95% CI: 3-23), a major complication occurred (3 disabling ischaemic strokes, 1 myocardial infarction, 1 acute interstitial nephropathy). In 7 patients (18%; 95% CI: 6-30), a minor complication occurred (5 transient ischaemic attacks, 1 transient confusional state, 1 non-disabling ischaemic stroke).
CONCLUSION
CAS cannot be considered as a routine procedure and should be restricted to high-risk patients unfit for surgery.
背景
尽管缺乏颈动脉血管成形术和支架置入术（CAS）安全性和有效性的证据，但该手术有时仍被用作手术的替代方案。
方法
在33个月的时间里，39例狭窄程度≥70%的连续患者接受了CAS（4例在随机试验中，35例因手术禁忌症）。
结果
5例患者（13%；95%置信区间：3 - 23）发生了严重并发症（3例致残性缺血性中风、1例心肌梗死、1例急性间质性肾病）。7例患者（18%；95%置信区间：6 - 30）发生了轻微并发症（5例短暂性脑缺血发作、1例短暂性意识模糊状态、1例非致残性缺血性中风）。
结论
CAS不能被视为常规手术，应仅限于不适合手术的高危患者。
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