心肌肥大。心脏细胞在发育过程中的分化与生长。
Cardiac-muscle hypertrophy. Differentiation and growth of the heart cell during development.
作者信息
Claycomb W C
出版信息
Biochem J. 1977 Dec 15;168(3):599-601. doi: 10.1042/bj1680599.
Abstract
An experimental model for the study of the control of tissue growth by cell proliferation (hyperplasia) and cell enlargement (hypertropht) is proposed. The model is constructed on the basis of the fact that, when DNA replication and cell proliferation cease in cardiac muscle during neonatal development, subsequent growth of the ventricular tissue is due to cell enlargement. The time period during development when this change in growth pattern occurs is documented with the cessation of DNA replication and the synthesis and accumulation of myosin as biochemical parameters. It is suggested that adrenergic innervation of the heart may be the physiological signal that changes the growth pattern of the muscle from hyperplasia to hypertrophy.
摘要
提出了一个用于研究通过细胞增殖（增生）和细胞增大（肥大）来控制组织生长的实验模型。该模型基于这样一个事实构建：在新生儿发育过程中，当心肌中的DNA复制和细胞增殖停止时，心室组织随后的生长是由于细胞增大。用DNA复制的停止以及肌球蛋白的合成和积累作为生化参数，记录发育过程中这种生长模式变化发生的时间段。有人提出，心脏的肾上腺素能神经支配可能是将肌肉生长模式从增生转变为肥大的生理信号。
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