自身免疫性肝炎患者的类固醇诱导性白内障
Steroid-induced cataracts in patients with autoimmune hepatitis.
作者信息
De Tommaso Adriana M, Santos Daniela S, Novaes Priscila, Arieta C E, Hessel G
机构信息
Pediatric Gastroenterology Unit, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Brazil.
出版信息
Acta Gastroenterol Latinoam. 2003;33(2):93-7.
BACKGROUND
Posterior subcapsular cataract (PSC) has been reported in patients on corticosteroids therapy for various pathologies. Autoimmune hepatitis (AIH) is a progressive inflammatory hepatic disease for which corticosteroids are recommended but PSC has not yet been reported in AIH patients on corticosteroids therapy.
METHODS
The AIH patients at our service underwent an ophthalmological assessment and their files were analyzed establish the dosage and duration of medication, the presence of visual complaints and the type of AIH, in order to correlate these with the ophthalmological findings. Patients were examined with a slit lamp following pupil dilation.
RESULTS
17 AIH patients evaluated, only one patient had PSC.
CONCLUSION
Although the frequency of PSC was low (1/17) in AIH patients on costicosteroid therapy, these individuals should undergo occasional ophthalmological assessment for the presence of cataracts since their visual acuity and quality of life may be adversely affected.
背景
有报道称，接受皮质类固醇治疗的各类疾病患者会出现后囊下白内障（PSC）。自身免疫性肝炎（AIH）是一种进行性炎症性肝病，推荐使用皮质类固醇进行治疗，但尚未有接受皮质类固醇治疗的AIH患者出现PSC的报道。
方法
我们科室的AIH患者接受了眼科评估，并分析他们的病历以确定用药剂量和时长、视觉症状的存在情况以及AIH的类型，以便将这些与眼科检查结果相关联。患者在散瞳后用裂隙灯进行检查。
结果
评估了17例AIH患者，只有1例患者患有PSC。
结论
尽管接受皮质类固醇治疗的AIH患者中PSC的发生率较低（1/17），但这些患者应定期接受眼科评估以检查是否存在白内障，因为这可能会对他们的视力和生活质量产生不利影响。
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