Samuelson U E, Hedén P, Jernbeck J, Wiklund N P
Department of Plastic and Reconstructive Surgery, Sabbatsbergs Hospital, Stockholm, Sweden.
Scand J Plast Reconstr Surg Hand Surg. 1992;26(3):241-5. doi: 10.3109/02844319209015265.
An island buttock flap based on the deep circumflex iliac artery and vein was raised in four pigs. Cutaneous laser Doppler blood flow (LDF) and total venous outflow (VO) from the flaps were measured. Intra-arterial infusion of endothelin-1 (0.3-2.5 nmol) through a branch of the deep circumflex iliac artery induced a pronounced and long lasting decrease in both LDF and VO. The maximal mean reductions being 95.3% and 73%, respectively, were seen within 5 minutes of the infusion. Intra-arterial infusions of endothelin in the circumflex iliac artery on the contralateral side caused a considerable reduction in intact skin LDF. Endothelin has potent vasoconstricting properties and its possible release and effect must be considered in reconstructive surgery.
在四只猪身上掀起了基于旋髂深动静脉的岛状臀瓣。测量了皮瓣的皮肤激光多普勒血流（LDF）和总静脉流出量（VO）。通过旋髂深动脉的一个分支动脉内输注内皮素-1（0.3 - 2.5 nmol），可导致LDF和VO均出现明显且持久的降低。输注后5分钟内，最大平均降幅分别为95.3%和73%。在对侧旋髂动脉内动脉内输注内皮素，可使完整皮肤的LDF显著降低。内皮素具有强大的血管收缩特性，在重建手术中必须考虑其可能的释放及作用。
