Zimmermann M, Nentwig G H
Klinik und Poliklinik für Kieferchirurgie, Universität München.
Schweiz Monatsschr Zahnmed. 1992;102(11):1327-32.
In a controlled clinical study with a total of 200 patients the broad spectrum agent and antitoxin taurolidine (Taurolin) was clearly superior to conventional medication with the broad spectrum antibiotic chlortetracycline (Aureomycin) when applied topically to treat the postextraction syndrome. Thus, the mean duration of therapy (primary target criterion) with Taurolin (group A) was 5.6 days compared to 8.2 days with the standard therapy (group B). In statistical terms this difference was highly significant (p < 0.0001). Compared with the conventionally treated patient group, the clinical control parameters such as pain, swelling, secretion, tenderness to pressure and remission (secondary target criteria) in the Taurolin group exhibited not only a markedly more rapid normalisation of the score-data during the initial phase, but also an appreciably shorter interval until the patients were symptom-free. Age, gender, localisation of the lesion or facultative systemic antibiotic or analgetic administration had no demonstrable effect on the course of the treatment, although the patients in the reference group required concomitant medication with antibiotics (p = 0.007) and analgetics (p = 0.01) considerably more often than those in the Taurolin group.
在一项共有200名患者参与的对照临床研究中，广谱制剂及抗毒素陶罗林（Taurolin）在局部应用治疗拔牙后综合征时，明显优于使用广谱抗生素金霉素（Aureomycin）的传统药物治疗。因此，陶罗林治疗组（A组）的平均治疗时长（主要指标）为5.6天，而标准治疗组（B组）为8.2天。从统计学角度来看，这一差异极为显著（p < 0.0001）。与传统治疗的患者组相比，陶罗林组的临床控制参数，如疼痛、肿胀、分泌物、压痛和缓解情况（次要指标），不仅在初始阶段评分数据的正常化明显更快，而且患者无症状的间隔时间也明显更短。年龄、性别、病变部位或是否使用全身性抗生素或镇痛药，对治疗过程均无明显影响，不过，参照组患者使用抗生素（p = 0.007）和镇痛药（p = 0.01）的频率明显高于陶罗林组患者。
