Heaney Robert P
Creighton University Medical Center, Omaha, Neb 68131, USA.
Mayo Clin Proc. 2004 Jan;79(1):91-7. doi: 10.4065/79.1.91.
Bone mineral consists of calcium phosphate, and phosphorus is as important as calcium in supporting bone augmentation and maintenance. Although typical adult diets contain abundant phosphorus, 10% to 15% of older women have intakes of less than 70% of the recommended daily allowance. When these women take high-dose calcium supplements that consist of the carbonate or citrate salts, all their food phosphorus may be bound and hence unavailable for absorption. Current-generation anabolic agents for treating osteoporosis require positive phosphorus balances of up to 90 mg/d. Attention to the nutritional adequacy of the diets of such patients is essential if they are to realize the full potential of such therapies. A calcium phosphate supplement may be preferable to the usual carbonate or citrate salts because its phosphate serves to spare food phosphorus.
骨矿物质由磷酸钙组成,在支持骨骼生长和维持方面,磷与钙同样重要。尽管典型的成人饮食含有丰富的磷,但10%至15%的老年女性摄入量低于推荐每日摄入量的70%。当这些女性服用由碳酸盐或柠檬酸盐组成的高剂量钙补充剂时,她们所有食物中的磷可能会被结合,因此无法吸收。目前用于治疗骨质疏松症的新一代合成代谢药物需要高达90毫克/天的正磷平衡。如果这类患者要充分发挥此类疗法的潜力,关注其饮食的营养充足性至关重要。磷酸钙补充剂可能比常用的碳酸盐或柠檬酸盐更可取,因为其磷有助于节省食物中的磷。