Inpan Ratchanon, Dukaew Nahathai, Na Takuathung Mingkwan, Teekachunhatean Supanimit, Koonrungsesomboon Nut
Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
Clinical Research Center for Food and Herbal Product Trials and Development (CR-FAH), Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
Arch Osteoporos. 2024 Dec 21;20(1):2. doi: 10.1007/s11657-024-01467-3.
This study examined how isoflavone interventions impact bone health in postmenopausal women. Analyzing 73 trials found that isoflavones reduce bone resorption markers, enhance bone minerals, and increase hormones regulating bone metabolism. This suggests that isoflavones could help address bone health issues in postmenopausal women.
This study aimed to assess the impact of isoflavone interventions on bone turnover markers and various biochemical markers of bone metabolism through systematic review and meta-analysis.
Four electronic databases, including PubMed, Embase, Scopus, and Cochrane Library, were searched in September 2023 for investigating the effects of isoflavones on bone turnover markers as well as signaling molecules regulating osteoclast differentiation, bone minerals, and hormones regulating bone metabolism in postmenopausal women. The main effect estimates, obtained using a random-effects model, were summarized using the mean difference (MD) or standardized mean difference (SMD), as appropriate.
A total of 73 randomized controlled trials were included, comparing an isoflavone intervention to a placebo. Our findings demonstrated that isoflavone interventions significantly reduced bone resorption markers, that is, β cross-linked C-telopeptide of type 1 collagen (β-CrossLaps) (MD = - 0.0943 ng/mL; P = 0.0071) and pyridinoline (PYD) (SMD = - 0.9111; P = 0.0247). Moreover, isoflavone interventions positively affected bone mineral parameters by increasing serum calcium levels (MD = 0.3430 mg/dL; P = 0.0267) and decreasing serum phosphorus levels (MD = - 0.0648 mg/dL; P = 0.0435). Hormones involved in regulating bone metabolism, particularly insulin-like growth factor type 1 (IGF-1), exhibited significant increases following isoflavone interventions (MD = 9.8163 ng/mL; P < 0.0001). Subgroup analysis suggested that the effects of isoflavones on bone turnover markers are influenced by factors such as the duration since menopause and the intervention duration.
This systematic review and meta-analysis highlight the potential of isoflavone interventions to rectify imbalances in bone remodeling, enhance bone mineral homeostasis, and optimize hormones regulating bone metabolism in postmenopausal women.
本研究探讨了异黄酮干预对绝经后女性骨骼健康的影响。对73项试验进行分析发现，异黄酮可降低骨吸收标志物，增加骨矿物质，并提高调节骨代谢的激素水平。这表明异黄酮有助于解决绝经后女性的骨骼健康问题。
本研究旨在通过系统评价和荟萃分析，评估异黄酮干预对骨转换标志物及各种骨代谢生化标志物的影响。
2023年9月检索了四个电子数据库，包括PubMed、Embase、Scopus和Cochrane图书馆，以研究异黄酮对绝经后女性骨转换标志物以及调节破骨细胞分化的信号分子、骨矿物质和调节骨代谢的激素的影响。使用随机效应模型获得的主要效应估计值，酌情用平均差（MD）或标准化平均差（SMD）进行汇总。
共纳入73项随机对照试验，将异黄酮干预与安慰剂进行比较。我们的研究结果表明，异黄酮干预显著降低了骨吸收标志物，即1型胶原β交联C末端肽（β-CTX）（MD = -0.0943 ng/mL；P = 0.0071）和吡啶啉（PYD）（SMD = -0.9111；P = 0.0247）。此外，异黄酮干预通过提高血清钙水平（MD = 0.3430 mg/dL；P = 0.0267）和降低血清磷水平（MD = -0.0648 mg/dL；P = 0.0435），对骨矿物质参数产生了积极影响。参与调节骨代谢的激素，特别是胰岛素样生长因子1（IGF-1），在异黄酮干预后显著增加（MD = 9.8163 ng/mL；P < 0.0001）。亚组分析表明，异黄酮对骨转换标志物的影响受绝经后时间和干预持续时间等因素影响。
本系统评价和荟萃分析强调了异黄酮干预在纠正绝经后女性骨重塑失衡、增强骨矿物质稳态以及优化调节骨代谢的激素方面的潜力。
