Shen Ya-Ching, Wang Li-Tung, Wang Chih-Hsin, Khalil Ashraf Taha, Guh Jih-Hwa
Institute of Marine Resources, National Sun Yat-sen University, 70 Lien-Hai Road, Kaohsiung, Taiwan, Republic of China.
Chem Pharm Bull (Tokyo). 2004 Jan;52(1):108-10. doi: 10.1248/cpb.52.108.
In addition to casearlucin A (3), two new clerodane diterpenes, caseamembrols A (1) and B (2) have been isolated from the leaves and twigs of Casearia membranacea by bioassay-guided fractionation. The structures of the new compounds were established on the basis of extensive 1D- and 2D-NMR spectroscopic analysis. Compounds 1-3 exhibited significant cytotoxicity against human prostate (PC-3) cancer cells.
除了酪木素A（3）之外，通过生物活性导向分离法，从膜叶嘉赐树的叶和嫩枝中分离出了两种新的克罗烷二萜类化合物，酪木醇A（1）和酪木醇B（2）。基于广泛的一维和二维核磁共振光谱分析确定了新化合物的结构。化合物1 - 3对人前列腺（PC - 3）癌细胞表现出显著的细胞毒性。
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