Lowder Jerry L, Shackelford Donald P, Holbert Don, Beste Todd M
Department of Obstetrics and Gynecology, Brody School of Medicine, Greenville, NC, USA.
Am J Obstet Gynecol. 2003 Dec;189(6):1559-62; discussion 1562. doi: 10.1016/j.ajog.2003.08.014.
The purpose of this study was to determine whether postcesarean section administration of ketorolac tromethamine reduces pain and narcotic usage.
A double-blinded randomized, placebo-controlled trial of ketorolac tromethamine was performed. Patients were randomly assigned to receive either ketorolac tromethamine or placebo. Patient-controlled analgesia (PCA) was used for pain control. Visual analog scales (VAS) were administered postoperatively to assess pain levels. Morphine equivalents and attempts were recorded.
There were 22 patients in each arm of the study. There was no significant difference between patient demographics, blood loss, and type of anesthesia. Pain scores were significantly different at 2, 3, 4, 6, 12, and 24 hours by analysis of variance (ANOVA) (P=.033). There was a significant decrease in pain medication usage (P=.008) in the study group.
Ketorolac tromethamine is efficacious in reducing postoperative pain and narcotics usage after cesarean section.
本研究旨在确定剖宫产术后给予酮咯酸氨丁三醇是否能减轻疼痛并减少麻醉剂使用量。
进行了一项关于酮咯酸氨丁三醇的双盲随机、安慰剂对照试验。患者被随机分配接受酮咯酸氨丁三醇或安慰剂。采用患者自控镇痛（PCA）来控制疼痛。术后使用视觉模拟量表（VAS）评估疼痛程度。记录吗啡等效剂量及使用次数。
研究的每组有22名患者。患者人口统计学特征、失血量和麻醉类型之间无显著差异。通过方差分析（ANOVA），在术后2、3、4、6、12和24小时疼痛评分有显著差异（P = 0.033）。研究组的止痛药物使用量显著减少（P = 0.008）。
酮咯酸氨丁三醇在减轻剖宫产术后疼痛和减少麻醉剂使用方面有效。
