药理学在胸主动脉重建术中脊髓保护方面的作用。
The role of pharmacology in spinal cord protection during thoracic aortic reconstruction.
作者信息
Reece T Brett, Kern John A, Tribble Curtis G, Cassada David C
机构信息
Department of Surgery, Division of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, VA 22908, USA.
出版信息
Semin Thorac Cardiovasc Surg. 2003 Oct;15(4):365-77. doi: 10.1053/s1043-0679(03)00088-1.
Surgery of the thoracic aorta continues to have a significant risk of neurologic complication. Several strategies to minimize this risk are emerging. Pharmacologic protection from these complications continues to be researched, but at this point few medications are being used clinically. This article reviews the pathophysiology of ischemic spinal cord injury and summarizes the investigational pharmacology that may prevent these serious complications.
胸主动脉手术仍具有较高的神经并发症风险。目前正在出现几种将这种风险降至最低的策略。针对这些并发症的药物保护措施仍在研究中，但目前临床上使用的药物很少。本文回顾了缺血性脊髓损伤的病理生理学，并总结了可能预防这些严重并发症的研究性药理学。
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