Cenk Sayin N, Gücer F, Balkanli-Kaplan P, Ali Yüce M, Yardim T
Department of Obstetrics and Gynecology, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey.
Gynecol Endocrinol. 2003 Oct;17(5):387-96. doi: 10.1080/09513590312331290278.
The aim of this study was to investigate carbohydrate and lipid profiles in women with polycystic appearing ovaries (PCO) on ultrasound examination who did not fulfill the criteria for polycystic ovary syndrome (PCOS). We sonographically evaluated and biochemically diagnosed 35 patients with PCO, 31 women with PCOS and 23 healthy controls. We performed oral glucose tolerance tests (OGTT) and calculated the quantitative insulin sensitivity check index (QUICKI) and the homeostatic model assessment (HOMAIR) scores. Serum fasting insulin levels, 1-h insulin response, HOMAIR and QUICKI scores were significantly higher in the PCO and PCOS groups than in the controls. However, serum fasting glucose levels, fasting insulin levels, HOMAIR and QUICKI scores were similar in women with PCO and PCOS. In women with PCO, high-density lipoprotein (HDL) levels were higher, and very-low-density lipoprotein (VLDL) and triglyceride levels were lower compared with women with PCOS. Furthermore, insulin responses to OGTT, HOMAIR and QUICKI scores and lipid values correlated with serum androgen levels and body mass index (BMI) in PCO patients. In conclusion, women with PCO who do not fulfill the criteria for PCOS have abnormal insulin sensitivity and insulin resistance. The finding of similar insulin abnormalities in women with PCO to those in women with PCOS confirms that women with PCO have similar metabolic characteristics to those with PCOS.
本研究的目的是调查超声检查显示有多囊样卵巢（PCO）但不符合多囊卵巢综合征（PCOS）标准的女性的碳水化合物和脂质谱。我们对35例PCO患者、31例PCOS女性和23名健康对照者进行了超声评估和生化诊断。我们进行了口服葡萄糖耐量试验（OGTT），并计算了定量胰岛素敏感性检查指数（QUICKI）和稳态模型评估（HOMAIR）得分。PCO组和PCOS组的血清空腹胰岛素水平、1小时胰岛素反应、HOMAIR和QUICKI得分显著高于对照组。然而，PCO女性和PCOS女性的血清空腹血糖水平、空腹胰岛素水平、HOMAIR和QUICKI得分相似。与PCOS女性相比，PCO女性的高密度脂蛋白（HDL）水平较高，极低密度脂蛋白（VLDL）和甘油三酯水平较低。此外，PCO患者对OGTT的胰岛素反应、HOMAIR和QUICKI得分以及脂质值与血清雄激素水平和体重指数（BMI）相关。总之，不符合PCOS标准的PCO女性存在胰岛素敏感性和胰岛素抵抗异常。PCO女性与PCOS女性胰岛素异常相似的发现证实，PCO女性与PCOS女性具有相似的代谢特征。
