Battaglia Cesare, Mancini Fulvia, Cianciosi Arianna, Busacchi Paolo, Facchinetti Fabio, Marchesini Giulio Reggiani, Marzocchi Rebecca, de Aloysio Domenico
Department of Obstetrics and Gynecology, University of Bologna, Bologna, Italy.
Obstet Gynecol. 2008 Feb;111(2 Pt 1):385-95. doi: 10.1097/01.AOG.0000296657.41236.10.
To estimate if young polycystic ovary syndrome (PCOS) patients have subclinical risks of vascular disease compared with eumenorrheic polycystic ovary (PCO) women and healthy controls.
Twenty-eight PCOS patients, 17 eumenorrheic PCO women, and 15 healthy eumenorrheic volunteers underwent medical examination; blood measurement of nitrites/nitrates, biochemical and hormonal parameters; uteroovarian ultrasonographic analysis and color Doppler evaluation of uterine, stromal ovarian, and ophthalmic arteries; brachial artery flow-mediated vasodilatation; 24-hour ambulatory blood pressure monitoring. An oral glucose tolerance test was performed to analyze glucose, insulin, and C-peptide.
Doppler analysis revealed a significantly higher uterine pulsatility index in the PCOS group compared with controls. The lowest vascular resistances in the ovaries were found in PCOS and PCO compared with controls. The ophthalmic artery back pressure was significantly higher in women with PCOS than in controls. The brachial artery diameter, at baseline, was similar in all the participants. After the reactive hyperemia, a greater vasodilatation was observed in controls and PCO patients in comparison with PCOS women. Total cholesterol, triglycerides, and the atherogenic plasma index were significantly higher in PCOS than PCO and controls. Leukocytes and homocysteine were slightly higher in PCOS. The nitrites/nitrates plasma levels were lower in PCOS and PCO patients compared with controls. The insulin and C-peptide plasma values were higher in PCOS patients than controls. In PCOS patients the different estimates of insulin sensitivity and pancreatic beta-cell function were higher compared with PCO and controls.
Polycystic ovary syndrome is a condition associated with an increased vascular risk.
II.
评估多囊卵巢综合征（PCOS）年轻患者与月经正常的多囊卵巢（PCO）女性及健康对照相比是否存在血管疾病的亚临床风险。
28例PCOS患者、17例月经正常的PCO女性和15例月经正常的健康志愿者接受了医学检查；检测血液中的亚硝酸盐/硝酸盐、生化和激素参数；进行子宫卵巢超声分析以及子宫、卵巢基质和眼动脉的彩色多普勒评估；检测肱动脉血流介导的血管舒张功能；进行24小时动态血压监测。进行口服葡萄糖耐量试验以分析血糖、胰岛素和C肽。
多普勒分析显示，PCOS组的子宫搏动指数显著高于对照组。与对照组相比，PCOS和PCO患者卵巢的血管阻力最低。PCOS女性的眼动脉舒张压显著高于对照组。所有参与者的肱动脉直径在基线时相似。反应性充血后，与PCOS女性相比，对照组和PCO患者观察到更大的血管舒张。PCOS患者的总胆固醇、甘油三酯和致动脉粥样硬化血浆指数显著高于PCO患者和对照组。PCOS患者的白细胞和同型半胱氨酸略高。与对照组相比，PCOS和PCO患者的血浆亚硝酸盐/硝酸盐水平较低。PCOS患者的血浆胰岛素和C肽值高于对照组。与PCO患者和对照组相比，PCOS患者对胰岛素敏感性和胰岛β细胞功能的不同评估更高。
多囊卵巢综合征是一种与血管风险增加相关的疾病。
II级。
