Bayram F, Müderris I, Güven M, Ozçelik B, Keleştimur F
Erciyes University Medical Faculty, Department of Endocrinology and Metabolism, 38039, Kayseri, Turkey.
Gynecol Endocrinol. 2003 Oct;17(5):419-22. doi: 10.1080/09513590312331290328.
This study was performed to confirm the therapeutic effects of low-dose, (2.5 mg/day) finasteride in hirsute women. Our study was a non-randomized prospective clinical trial. Twenty-nine patients with hirustism were included in the study. The patients received 2.5 mg finasteride once a day over a period of 12 months. Follicle stimulating hormone, luteinizing hormone, sex hormone binding globulin, 17 alpha-hydroxyprogesterone, estradiol, androstenedione, total and free testosterone, dehydroepiandrosterone sulfate levels and hirsutism scores were determined in all patients before treatment and at every 6 months during the therapy. The hirsutism score decreased from a mean of 18.4 +/- 4.6 to 8.4 +/- 4.2 during the study. The per cent reduction in hirsutism score (mean +/- SD) at 6 and 12 months was 29.2 +/- 14.5 and 55.7 +/- 14.9%, respectively. There were no significant differences in any of the hormone levels and no serious side-effects were observed during the treatment. In conclusion, low-dose finasteride (2.5 mg/day) is a cost-effective, well-tolerated therapeutic agent without significant abnormal biochemical findings and can be used in place of high-dose (5 mg/day) finasteride in the treatment of hirsutism.
本研究旨在证实低剂量（2.5毫克/天）非那雄胺对多毛症女性的治疗效果。我们的研究是一项非随机前瞻性临床试验。29例多毛症患者纳入研究。患者每天服用一次2.5毫克非那雄胺，为期12个月。在所有患者治疗前及治疗期间每6个月测定促卵泡激素、促黄体生成素、性激素结合球蛋白、17α-羟孕酮、雌二醇、雄烯二酮、总睾酮和游离睾酮、硫酸脱氢表雄酮水平及多毛症评分。研究期间，多毛症评分从平均18.4±4.6降至8.4±4.2。6个月和12个月时多毛症评分降低百分比（均值±标准差）分别为29.2±14.5%和55.7±14.9%。治疗期间激素水平均无显著差异，未观察到严重副作用。总之，低剂量非那雄胺（2.5毫克/天）是一种经济有效、耐受性良好的治疗药物，无显著生化异常发现，可用于替代高剂量（5毫克/天）非那雄胺治疗多毛症。
