Unluhizarci K, Ozel D, Tanriverdi F, Karaca Z, Kelestimur F
Department of Endocrinology, Erciyes University Medical School, Kayseri, Turkey.
J Endocrinol Invest. 2009 Jan;32(1):37-40. doi: 10.1007/BF03345676.
To investigate the clinical efficacy and safety of the finasteride (5 mg/day) plus flutamide (125 mg/day) combination therapy in unselected women with hirsutism, 44 women were involved in the study. The effects of such combination treatment have not been reported previously. The patients were assigned to 3 treatment groups: 14 patients (group 1) were treated with finasteride (5 mg per day), 16 patients (group 2) were treated with flutamide (125 mg per day), and 14 patients (group 3) were treated with finasteride (5 mg per day) plus flutamide (125 mg per day) for 12 months. Serum FSH, LH, estradiol, total testosterone, free testosterone, androstenedione, DHEAS, and SHBG were obtained. Hirsutism score was measured before and after treatment. Blood chemistry and side effects were evaluated during the study. The reductions in hirsutism score (% of the baseline) at 6 months were as follows: 24% for group 1, 35% for group 2, and 33% for group 3. Combination therapy resulted in (49%) similar improvement to flutamide alone (45%), but significantly (p<0.05) more efficacious improvement in hirsutism when compared to finasteride (32%) after 12 months of treatment. In conclusion, flutamide is more effective than finasteride and the combination of these two drugs is not better than flutamide alone, but better than finasteride in hirsute women.
为研究非选择性多毛症女性患者使用非那雄胺（5毫克/天）联合氟他胺（125毫克/天）治疗的临床疗效及安全性，44名女性参与了该研究。此前尚未有关于这种联合治疗效果的报道。患者被分为3个治疗组：14名患者（第1组）接受非那雄胺（5毫克/天）治疗，16名患者（第2组）接受氟他胺（125毫克/天）治疗，14名患者（第3组）接受非那雄胺（5毫克/天）联合氟他胺（125毫克/天）治疗，为期12个月。检测血清促卵泡生成素（FSH）、促黄体生成素（LH）、雌二醇、总睾酮、游离睾酮、雄烯二酮、硫酸脱氢表雄酮（DHEAS）和性激素结合球蛋白（SHBG）。在治疗前后测量多毛症评分。在研究期间评估血液生化指标及副作用。6个月时多毛症评分降低幅度（相对于基线的百分比）如下：第1组为24%，第2组为35%，第3组为33%。联合治疗导致的改善（49%）与单独使用氟他胺（45%）相似，但在治疗12个月后，与非那雄胺（32%）相比，联合治疗在改善多毛症方面显著更有效（p<0.05）。总之，氟他胺比非那雄胺更有效，这两种药物联合使用并不比单独使用氟他胺更好，但在多毛症女性中比非那雄胺更好。
