Su Tianyun, Mulla Mir S, Zaim Morteza
Department of Entomology, University of California, Riverside, CA 92521, USA.
J Am Mosq Control Assoc. 2003 Dec;19(4):408-18.
Limited laboratory and field studies have indicated that the insect growth regulator (IGR) novaluron exhibits good activity against larvae of pest species in the orders Coleoptera, Hemiptera (suborder Heteroptera), and Lepidoptera by both ingestion and contact. We completed laboratory and field studies to evaluate activity and efficacy of novaluron against Culex mosquitoes. In laboratory studies, novaluron was highly active against Cx. quinquefasciatus, as indicated by low levels of inhibition of emergency (IE), at the 50% level, IE50 (0.159 ppb for 2nd-stage larvae and 0.118 ppb for 4th-stage larvae) and IE90, at the 90% level, (0.604 ppb for 2nd-stage larvae and 0.595 ppb for 4th-stage larvae). In outdoor microcosm and mesocosm studies against natural populations, novaluron yielded excellent control of immature Culex mosquitoes for up to 14 days at 1.25, 2.5, and 5 ppb in microcosms, and for up to 7 days at the dosages of 1, 5, and 10 mg/m2 in mesocosms. Based on qualitative observations, novaluron seemed to have a favorable margin of safety for nontarget aquatic invertebrates cohabiting with mosquito larvae. Further large-scale field studies are warranted to evaluate initial efficacy and longevity of novaluron against various mosquito species, as well as its safety for nontarget biota.
有限的实验室和田间研究表明，昆虫生长调节剂（IGR）诺瓦隆通过摄食和接触对鞘翅目、半翅目（异翅亚目）和鳞翅目害虫种类的幼虫均表现出良好的活性。我们完成了实验室和田间研究，以评估诺瓦隆对库蚊的活性和功效。在实验室研究中，诺瓦隆对致倦库蚊具有高活性表现为低水平的羽化抑制（IE），在50%水平时，IE50（二龄幼虫为0.159 ppb，四龄幼虫为0.118 ppb），在90%水平时，IE90（二龄幼虫为0.604 ppb，四龄幼虫为0.595 ppb）。在针对自然种群的室外微观和中观研究中，在微观环境中，诺瓦隆以1.25、2.5和5 ppb的剂量对未成熟库蚊产生了长达14天的出色防治效果，在中观环境中，以1、5和10 mg/m²的剂量对未成熟库蚊产生了长达7天的出色防治效果。基于定性观察，诺瓦隆对于与蚊幼虫共生的非靶标水生无脊椎动物似乎具有良好的安全边际。有必要开展进一步的大规模田间研究，以评估诺瓦隆对各种蚊种的初期功效和持效期，以及其对非靶标生物群的安全性。
