Entomological Surveillance Unit, Office of Regional Director of Health Services, Kurunegala, Sri Lanka.
Postgraduate Institute of Science, University of Peradeniya, Peradeniya, Sri Lanka.
Sci Rep. 2024 Jan 23;14(1):1988. doi: 10.1038/s41598-024-52384-x.
Insect Growth Regulator (IGR) novaluron is an alternative to synthetic neuro-inhibitory insecticides. Present study was designed to assess appropriate dosages of novaluron for dengue vector control. Larvae of Aedes aegypti and Ae. albopictus were exposed to a concentration series of novaluron (Rimon EC10) for two fixed exposure periods of 7-days and 14-days to determined LC and LC values. Inhibition of adult emergence (IE and IE) was determined by a 14-day exposure. Semi-field experiments were conducted by exposing cohorts of Ae. aegypti larvae to IE, 2 × IE and 10 × IE novaluron concentrations in water storage buckets (10 L) and plastic barrels (200 L). For the 7-day exposure, LC values were 0.047-0.049 ppm and LC were 0.144-0.151 ppm. For 14-day exposure, these values were 0.002-0.005 ppm and 0.006-0.01 ppm respectively. For both species, IE was 0.001 ppb under semi-field conditions, and was effective for nearly 2 months. Novaluron concentration 0.01 ppb was effective up to 3 months, with an IE of 89-95%. Authorities should critically review a reduction of the presently recommended field dosage of 200 ppm novaluron by × 100 or more. This would provide the same efficacy but mitigate environmental pollution, development of vector resistance, and financial losses.
昆虫生长调节剂（IGR）novaluron 是合成神经抑制剂杀虫剂的替代品。本研究旨在评估 novaluron 用于登革热病媒控制的适当剂量。埃及伊蚊和白纹伊蚊的幼虫分别暴露于一系列浓度的 novaluron（Rimon EC10）中，暴露期为 7 天和 14 天，以确定 LC 和 LC 值。通过 14 天的暴露来确定成虫出现抑制（IE 和 IE）。通过将 Ae. aegypti 幼虫暴露于 IE、2×IE 和 10×IE novaluron 浓度的储水桶（10 L）和塑料桶（200 L）中，进行半现场实验。对于 7 天的暴露，LC 值为 0.047-0.049 ppm，LC 值为 0.144-0.151 ppm。对于 14 天的暴露，这些值分别为 0.002-0.005 ppm 和 0.006-0.01 ppm。对于这两个物种，IE 在半现场条件下为 0.001 ppb，并且有效近 2 个月。0.01 ppb 的 novaluron 浓度有效达 3 个月，IE 为 89-95%。当局应认真审查目前推荐的 200 ppm novaluron 田间剂量减少 ×100 或更多。这将提供相同的效果，但减轻环境污染、病媒抗药性的发展和经济损失。
