Fu Yi, Finklea Harry O
Department of Chemistry, West Virginia University, Morgantown, West Virginia 26506, USA.
Anal Chem. 2003 Oct 15;75(20):5387-93. doi: 10.1021/ac034523b.
Molecularly imprinted polymers on quartz crystal microbalances (QCM) are examined for their ability to detect vapors of small organic molecules with greater sensitivity and selectivity than the traditional amorphous polymer coatings. Hydroquinone and phenol serve as noncovalently bound templates that generate shape-selective cavities in a poly(acrylic) or poly(methacrylic) polymer matrix. The imprinted polymers are immobilized on the piezoelectric crystal surface via a precoated poly(isobutylene) layer. The behavior of the imprinted polymer films is characterized by the dynamic and steady-state response of the QCM frequency to pulses of organic vapors in dry air. The apparent partition coefficients are determined for imprinted and nonimprinted polymers prepared by two synthetic methods and for varying mole ratios of template to monomer. The hydroquinone-imprinted polymers and, to a lesser extent, the phenol-imprinted polymers exhibit greater sensitivity and higher selectivity than the nonimprinted polymers toward organic vapors that are structurally related to the templates. These results indicate that molecularly imprinted polymers are promising for the development of selective piezoelectric sensors for organic vapor detection.
研究了石英晶体微天平（QCM）上的分子印迹聚合物用于检测小有机分子蒸汽的能力，其比传统的无定形聚合物涂层具有更高的灵敏度和选择性。对苯二酚和苯酚作为非共价结合的模板，在聚丙烯酸或聚甲基丙烯酸聚合物基质中产生形状选择性空腔。印迹聚合物通过预涂覆的聚异丁烯层固定在压电晶体表面。印迹聚合物膜的行为通过QCM频率对干燥空气中有机蒸汽脉冲的动态和稳态响应来表征。测定了通过两种合成方法制备的印迹和非印迹聚合物以及模板与单体不同摩尔比下的表观分配系数。与非印迹聚合物相比，对苯二酚印迹聚合物以及在较小程度上苯酚印迹聚合物对与模板结构相关的有机蒸汽表现出更高的灵敏度和选择性。这些结果表明，分子印迹聚合物在开发用于有机蒸汽检测的选择性压电传感器方面具有广阔前景。
