Walsh Simon J
Centre for Forensic Science, Department of Cell and Molecular Biology, University of Technology, Sydney, PO Box 123, Broadway, NSW, 2001, Australia.
Expert Rev Mol Diagn. 2004 Jan;4(1):31-40. doi: 10.1586/14737159.4.1.31.
Like many applications of molecular diagnostics, the field of forensic biology is undergoing a phase of expansion and diversification. The growth of forensic DNA databases and adoption of sophisticated analytical methods have catalyzed this increasing role. The range of molecular markers exploited in the fight against crime is beginning to increase too, and genes implying personal or physical characteristics are emerging in the research literature. However, the operational context of forensic biology is unlike many other fields of science. Harmonizing technological breakthroughs with the requirements of law enforcement agencies and the complexities of the legal system is an added challenge and one which evokes ongoing debate. This review examines the current status of this dynamic and important application of modern genetics.
与分子诊断的许多应用一样,法医生物学领域正处于扩张和多样化阶段。法医DNA数据库的增长以及先进分析方法的采用推动了这一作用的不断增强。用于打击犯罪的分子标记范围也开始扩大,研究文献中也出现了暗示个人或身体特征的基因。然而,法医生物学的操作环境与许多其他科学领域不同。将技术突破与执法机构的要求以及法律体系的复杂性相协调是一项额外的挑战,并且引发了持续的争论。本综述探讨了现代遗传学这一充满活力且重要应用的当前状况。