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利用基因分析鉴定骨骼遗骸:一起将意大利和波兰联系起来的案件。

Identification of Skeletal Remains Using Genetic Profiling: A Case Linking Italy and Poland.

机构信息

Section of Legal Medicine, Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.

Section of Molecular Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari "Aldo Moro", 70124 Bari, Italy.

出版信息

Genes (Basel). 2023 Jan 3;14(1):134. doi: 10.3390/genes14010134.

Abstract

Forensic genetics is a rapidly evolving science thanks to the growing variety of genetic markers, the establishment of faster, less error-prone sequencing technologies, and the engineering of bioinformatics models, methods, and structures. In the early 2000s, the need emerged to create an international genetic database for forensic purposes. This paper describes a judicial investigation of skeletal remains to identify the subject using various methods. The anthropological examination of the remains allowed identification of the Caucasoid (European) ethnic group, a height of 156 ± 4 cm, and an age between 47 and 50 years. The genetic profiles obtained from typing several microsatellites made it possible to evaluate the compatibility between the skeletal remains and the suspected decedent. To identify the remains, the two extrapolated genetic profiles were compared. The case described highlights the central role of forensic genetics in identifying skeleton remains by means of comparison.

摘要

法医学是一门快速发展的科学,这得益于遗传标记种类的不断增加、更快、出错更少的测序技术的建立,以及生物信息学模型、方法和结构的工程设计。在 21 世纪初,出现了为法医目的创建国际遗传数据库的需求。本文描述了一项使用各种方法对骨骼遗骸进行法医调查以识别主体的司法调查。对遗骸的人类学检查表明,其属于白种人(欧洲)族群,身高为 156±4 厘米,年龄在 47 岁至 50 岁之间。从对几个微卫星进行分型获得的遗传谱,使得评估骨骼遗骸与疑似死者之间的兼容性成为可能。为了识别遗骸,对两个推断的遗传谱进行了比较。所描述的案例突出了法医遗传学在通过比较来识别骨骼遗骸方面的核心作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c5e/9858830/61866f10fe75/genes-14-00134-g001.jpg

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