Balercia Giancarlo, Mosca Fabrizio, Mantero Franco, Boscaro Marco, Mancini Antonio, Ricciardo-Lamonica Giuseppe, Littarru GianPaolo
Department of Internal Medicine, Umberto I Hospital, School of Medicine, University of Ancona, Ancona, Italy.
Fertil Steril. 2004 Jan;81(1):93-8. doi: 10.1016/j.fertnstert.2003.05.009.
To clarify a potential therapeutic role of coenzyme Q(10) (CoQ(10)) in infertile men with idiopathic asthenozoospermia.
Open, uncontrolled pilot study.
PATIENT(S): Infertile men with idiopathic asthenozoospermia.
INTERVENTION(S): CoQ(10) was administered orally; semen samples were collected at baseline and after 6 months of therapy. MAIN OUTCOME MEASURE (S): Semen kinetic parameters, including computer-assisted sperm data and CoQ(10) and phosphatidylcholine levels.
RESULT(S): CoQ(10) levels increased significantly in seminal plasma and in sperm cells after treatment. Phosphatidylcholine levels also increased. A significant increase was also found in sperm cell motility as confirmed by computer-assisted analysis. A positive dependence (using the Cramer's index of association) was evident among the relative variations, baseline and after treatment, of seminal plasma or intracellular CoQ(10) content and computer-determined kinetic parameters.
CONCLUSION(S): The exogenous administration of CoQ(10) may play a positive role in the treatment of asthenozoospermia. This is probably the result of its role in mitochondrial bioenergetics and its antioxidant properties.
阐明辅酶Q(10)（CoQ(10)）在特发性弱精子症不育男性中的潜在治疗作用。
开放性、非对照性初步研究。
特发性弱精子症不育男性。
口服CoQ(10)；在基线时和治疗6个月后采集精液样本。
精液动力学参数，包括计算机辅助精子数据以及CoQ(10)和磷脂酰胆碱水平。
治疗后精浆和精子细胞中的CoQ(10)水平显著升高。磷脂酰胆碱水平也升高。经计算机辅助分析证实，精子细胞活力也显著增加。精浆或细胞内CoQ(10)含量在治疗前后的相对变化与计算机测定的动力学参数之间存在明显的正相关性（使用克莱默关联指数）。
外源性给予CoQ(10)可能在弱精子症治疗中发挥积极作用。这可能是其在线粒体生物能量学中的作用及其抗氧化特性的结果。
