肿瘤坏死因子在血吸虫感染过程中对限制肝脏病理变化及促进寄生虫存活方面的作用。
Involvement of TNF in limiting liver pathology and promoting parasite survival during schistosome infection.
作者信息
Davies Stephen J, Lim K C, Blank Rebecca B, Kim Jea-Hyoun, Lucas Kimberley D, Hernandez David C, Sedgwick Jonathon D, McKerrow James H
机构信息
Tropical Disease Research Unit, Department of Pathology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA.
出版信息
Int J Parasitol. 2004 Jan;34(1):27-36. doi: 10.1016/j.ijpara.2003.10.010.
CD4(+) T cell responses and macrophage activation are essential components of schistosome egg-induced granuloma formation. Previous studies implicated tumour necrosis factor (TNF) as a potential mediator of macrophage recruitment and activation during schistosome infection. Here we demonstrate that signalling by TNF and its receptors can influence granuloma formation, but is ultimately dispensable for granuloma formation in this system. However, we identify a previously unrecognised role for TNF in limiting hepatocellular damage in response to schistosome eggs. Further, we show that this activity of TNF is independent of TNF receptors (TNFR1 and TNFR2). Taken together, these data suggest that additional, as yet unrecognised receptors exist for TNF and that these receptors are capable of mediating important pathological effects in the liver. Finally, we provide evidence that TNF plays an unexpected role in maintaining adult schistosome viability in the portal system.
CD4(+) T细胞细胞细胞应答和巨噬细胞激活是血吸虫卵诱导肉芽肿形成的重要组成部分。先前的研究表明肿瘤坏死因子（TNF）是血吸虫感染期间巨噬细胞募集和激活的潜在介质。在此，我们证明TNF及其受体发出的信号可影响肉芽肿形成，但在该系统中肉芽肿形成最终并不依赖于它。然而，我们发现TNF在限制血吸虫卵引起的肝细胞损伤方面具有先前未被认识到的作用。此外，我们表明TNF的这种活性独立于TNF受体（TNFR1和TNFR2）。综上所述，这些数据表明TNF存在其他尚未被认识的受体，并且这些受体能够介导肝脏中的重要病理效应。最后，我们提供证据表明TNF在维持门静脉系统中成年血吸虫的活力方面发挥了意想不到的作用。
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