由赭曲霉产生的霉菌毒素赭曲霉毒素A天然类似物的分离与结构测定。
Isolation and structure determination of natural analogues of the mycotoxin ochratoxin A produced by Aspergillus ochraceus.
作者信息
Hadidane R, Bacha H, Creppy E E, Hammami M, Ellouze F, Dirheimer G
机构信息
Faculté de Médecine Dentaire, Université du Centre, Monastir, Tunisia.
出版信息
Toxicology. 1992 Dec 4;76(3):233-43. doi: 10.1016/0300-483x(92)90192-h.
Three new natural mycotoxins, analogues of ochratoxin A, in which the phenylalanine moiety is replaced by serine, hydroxyproline or lysine, were isolated from cultures of Aspergillus ochraceus by TLC followed by HPLC column chromatography. Their structures were determined after acidic hydrolysis by the characterisation of both their amino acid moieties and of ochratoxin alpha, the chlorinated dihydroisocoumarin moiety of ochratoxin A. These structures were confirmed by mass spectrum analysis.
从赭曲霉培养物中通过薄层色谱法（TLC）继以高效液相色谱柱色谱法分离出三种新的天然霉菌毒素，即赭曲霉毒素A的类似物，其中苯丙氨酸部分被丝氨酸、羟脯氨酸或赖氨酸取代。通过对其氨基酸部分以及赭曲霉毒素α（赭曲霉毒素A的氯化二氢异香豆素部分）进行表征，在酸性水解后确定了它们的结构。这些结构通过质谱分析得到证实。
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