区域异构体4-硝基吲唑N1-和N2-(β-D-核糖核苷)。
Regioisomeric 4-nitroindazole N1- and N2-(beta-D-ribonucleosides).
作者信息
Seela Frank, Peng Xiaohua, Eickmeier Henning, Reuter Hans
机构信息
Laboratorium für Organische und Bioorganische Chemie, Institut für Chemie, Universität Osnabrück, Barbarastrasse 7, 49069 Osnabrück, Germany.
出版信息
Acta Crystallogr C. 2004 Jan;60(Pt 1):o94-7. Epub 2003 Dec 20.
The structures of the isomeric nucleosides 4-nitro-1-(beta-D-ribofuranosyl)-1H-indazole, C(12)H(13)N(3)O(6), (I), and 4-nitro-2-(beta-D-ribofuranosyl)-2H-indazole, C(12)H(13)N(3)O(6), (II), have been determined. For compound (I), the conformation of the glycosylic bond is anti [chi = -93.6 (6) degrees ] and the sugar puckering is C2'-exo-C3'-endo. Compound (II) shows two conformations in the crystalline state which differ mainly in the sugar pucker; type 1 adopts the C2'-endo-C3'-exo sugar puckering associated with a syn base orientation [chi = 43.7 (6) degrees ] and type 2 shows C2'-exo-C3'-endo sugar puckering accompanied by a somewhat different syn base orientation [chi = 13.8 (6) degrees ].
已确定同分异构核苷4-硝基-1-(β-D-呋喃核糖基)-1H-吲唑，C(12)H(13)N(3)O(6)，(I)，和4-硝基-2-(β-D-呋喃核糖基)-2H-吲唑，C(12)H(13)N(3)O(6)，(II)的结构。对于化合物(I)，糖苷键的构象为反式[χ = -93.6 (6)°]，糖的折叠形式为C2'-外向-C3'-内向。化合物(II)在晶体状态下呈现两种构象，主要区别在于糖的折叠形式；1型采用与顺式碱基取向相关的C2'-内向-C3'-外向糖折叠形式[χ = 43.7 (6)°]，2型呈现C2'-外向-C3'-内向糖折叠形式，并伴有略有不同的顺式碱基取向[χ = 13.8 (6)°]。
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