Kalinowski M, Wagner H-J
Klinik für Strahlendiagnostik, Klinikum der Philipps-Universität Marburg.
Rofo. 2004 Jan;176(1):85-90. doi: 10.1055/s-2004-814659.
To evaluate one-molar Gadobutrol solution as contrast media for intra-arterial digital subtraction angiography (DSA).
In 10 patients (7 males, 3 females; mean age 68 years) with contraindications for the use of iodinated contrast media (n = 8 renal insufficiency, n = 2 previous allergic reaction), Gadobutrol solution (1 mol/l) was used as contrast media for DSA. Six diagnostic angiograms and four DSAs for percutaneous transluminal angioplasty (PTA) were performed.
In all cases, Gadobutrol yielded sufficient contrast for diagnostic DSA. Because of dose limitations (maximum 0.3 ml/kg body weight), small amounts of iodinated contrast media were administered to complete the angiographic procedure (mean 15 ml) in two patients. Allergic reactions were not recorded in any patient. In patients with pre-existing renal insufficiency, mean serum creatinine level was not statistically significant different from the initial level (mean 2.88 mg/dl before and 2.83 mg/dl after DSA). Selective injection of Gadobutrol resulted in temporary discomfort.
One molar Gadobutrol is an alternate contrast media for DSA in patients with contraindications for iodinated contrast media. Current dose limitations require selective injections.
评估1摩尔钆布醇溶液作为动脉内数字减影血管造影（DSA）的造影剂。
10例患者（7例男性，3例女性；平均年龄68岁）存在使用碘化造影剂的禁忌证（8例肾功能不全，2例既往有过敏反应），使用钆布醇溶液（1摩尔/升）作为DSA的造影剂。进行了6次诊断性血管造影和4次经皮腔内血管成形术（PTA）的DSA。
在所有病例中，钆布醇产生了足够的对比度用于诊断性DSA。由于剂量限制（最大0.3毫升/千克体重），两名患者中给予了少量碘化造影剂以完成血管造影程序（平均15毫升）。所有患者均未记录到过敏反应。在已有肾功能不全的患者中，平均血清肌酐水平与初始水平相比无统计学显著差异（DSA前平均为2.88毫克/分升，DSA后为2.83毫克/分升）。选择性注射钆布醇会导致暂时不适。
1摩尔钆布醇是碘化造影剂禁忌患者DSA的替代造影剂。目前的剂量限制需要选择性注射。
