Oehler Martin K, Wain Gerard V, Brand Alison
Department of Gynaecological Oncology, Westmead Hospital, University of Sydney, Westmead, New South Wales, Australia.
Aust N Z J Obstet Gynaecol. 2003 Dec;43(6):414-20. doi: 10.1046/j.0004-8666.2003.00151.x.
Gynaecological malignancies frequently occur in women of reproductive age and are estimated to complicate approximately one in 1000 pregnancies. The incidence of gynaecological malignancies during pregnancy is expected to rise as more women delay childbearing into their later reproductive years, and maternal age is the most powerful predictor of cancer risk. Pregnancy-associated malignancies present significant challenges as a result of the conflict between optimal maternal therapy and fetal well-being. The lack of prospective randomised treatment studies has prevented the development of clinical guidelines for most of the issues complicating the management. In the present review, recent diagnostic and treatment strategies for cervical, ovarian, vulvar and endometrial carcinomas during pregnancy are presented.
妇科恶性肿瘤常见于育龄女性，据估计每1000例妊娠中约有1例会并发该疾病。随着越来越多的女性将生育推迟到其生育后期，孕期妇科恶性肿瘤的发病率预计将会上升，而产妇年龄是癌症风险的最有力预测因素。由于最佳的母体治疗与胎儿健康之间存在冲突，妊娠相关恶性肿瘤带来了重大挑战。缺乏前瞻性随机治疗研究阻碍了针对大多数管理复杂性问题制定临床指南。在本综述中，介绍了孕期宫颈癌、卵巢癌、外阴癌和子宫内膜癌的最新诊断和治疗策略。
