Topashka-Ancheva Margarita, Taskova Rilka, Handjieva Nedjalka, Mikhova Bozhanka, Duddeck Helmut
Institute of Zoology, Bulgarian Academy of Sciences, 1000 Sofia, Bulgaria.
Z Naturforsch C J Biosci. 2003 Nov-Dec;58(11-12):833-6. doi: 10.1515/znc-2003-11-1216.
The clastogenic effect of total dichloromethane, methanol and water extracts, four bioactive fractions and three individual constituents from Carthamus lanatus aerial parts were evaluated in mice by bone marrow chromosome aberration assay with mitomycin C as positive control. Significant differences in the percentage of aberrant mitosis of the extracts were observed. The dichloromethane extract exhibited a considerable clastogenic effect and the water extract a negligible one. Different types of chromosome aberrations and time-dependant effects for the active fractions and individual compounds were found.
采用丝裂霉素C作为阳性对照，通过骨髓染色体畸变试验，评估了来自红花鼠尾草地上部分的总二氯甲烷、甲醇和水提取物、四种生物活性组分以及三种单一成分对小鼠的致断裂效应。观察到提取物的异常有丝分裂百分比存在显著差异。二氯甲烷提取物表现出相当大的致断裂效应，而水提取物的效应可忽略不计。还发现了活性组分和单一化合物的不同类型染色体畸变及时间依赖性效应。
