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地方产佩特拉克提取物针对过氧化氢诱导毒性的综合抗基因毒性概况。

Comprehensive antigenotoxic profile of endemic Petrak extracts against hydrogen peroxide induced toxicity.

作者信息

Bayhan Hamza, Dogan Serap, Yilmaz Kardas Begumhan, Diken Mehmet Emin, Dirmenci Tuncay, Celikler Serap

机构信息

Present Address: Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Bahcesehir University, Istanbul, Turkey.

Present Address: Department of Molecular Biology and Genetics, Faculty of Science and Literature, Balikesir University, Balikesir, Turkey.

出版信息

Food Sci Biotechnol. 2024 Apr 24;33(13):3131-3152. doi: 10.1007/s10068-024-01555-7. eCollection 2024 Oct.

Abstract

Cyto/genotoxicity have been widespread utilized for the safety risk assessment of synthetic/natural chemicals. Plants can protect organisms from harmful effects of xenobiotics. On the other hand, plants can extract toxic molecules from the environment which may disrupt mitosis and cytokinesis. However, the precise role of during this process is unknown. We showed that didn't cause cyto/genotoxicity. Findings showed powerful inhibition in micronucleus formation and they are safe for healthy human lymphocytes in terms of their capacity to generate chromosomal aberrations. They caused significant increases in sister chromatid exchange (SCE) compared to control but they were able to decrease SCE frequency caused by HO. Additionally, the antibacterial efficiencies of the samples against and were up to 50% of the effectivity of penicillin/streptomycin. was able to protect the organism from the oxidative damage and didn't affect the normal developmental phases of .

摘要

细胞/遗传毒性已被广泛用于合成/天然化学品的安全风险评估。植物可以保护生物体免受异生物素的有害影响。另一方面,植物可以从环境中提取可能干扰有丝分裂和胞质分裂的有毒分子。然而,在此过程中 的精确作用尚不清楚。我们表明 不会引起细胞/遗传毒性。研究结果显示对微核形成有强大的抑制作用,就其产生染色体畸变的能力而言,它们对健康人类淋巴细胞是安全的。与对照组相比,它们导致姐妹染色单体交换(SCE)显著增加,但它们能够降低由HO引起的SCE频率。此外,样品对 和 的抗菌效率高达青霉素/链霉素有效性的50%。 能够保护生物体免受氧化损伤,并且不影响 的正常发育阶段。

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