Zerkak Djamila, Dougados Maxime
Rheumatology B Department, René Descartes University, AP-HP Cochin Hospital, 27 rue du Faubourg Saint Jacques, Paris 75014, France.
Curr Rheumatol Rep. 2004 Feb;6(1):41-5. doi: 10.1007/s11926-004-0082-4.
Glucosamine products have been used extensively for the management of pain in osteoarthritis. This paper reviews the most recent clinical and experimental studies regarding its efficacy and safety. Although clinical trials include methodologic flaws and publication bias, glucosamine is likely an effective therapy for the symptomatic management of osteoarthritis. In turn, definite proof for chondromodulating effect requires well-conducted clinical trials. In North America, glucosamine is an over-the-counter dietary supplement and preparations made by different manufacturers may vary. There is also a need to standardize this therapy and allow practitioners to give patients suitable advice. An ongoing long-term clinical trial in the US will possibly permit to investigate the clinical relevance of these results and give appropriate recommendations.
氨基葡萄糖产品已被广泛用于骨关节炎疼痛的管理。本文综述了关于其疗效和安全性的最新临床和实验研究。尽管临床试验存在方法学缺陷和发表偏倚，但氨基葡萄糖可能是骨关节炎症状管理的有效疗法。反过来，软骨调节作用的确切证据需要开展良好的临床试验。在北美，氨基葡萄糖是一种非处方膳食补充剂，不同制造商生产的制剂可能有所不同。还需要规范这种疗法，并让从业者能够为患者提供合适的建议。美国正在进行的一项长期临床试验可能会有助于研究这些结果的临床相关性并给出适当的建议。
