Frech Tracy M, Clegg Daniel O
Division of Rheumatology, University of Utah School of Medicine, George E. Wahlen Veterans Affairs Medical Center, 4B200 School of Medicine, 50 North Medical Drive, Salt Lake, UT 84132, USA.
Curr Rheumatol Rep. 2007 Apr;9(1):25-30. doi: 10.1007/s11926-007-0018-x.
Osteoarthritis (OA) treatment is limited by the inability of prescribed medications to alter disease outcome. As a result, patients with OA often take food substances called nutraceuticals in an attempt to affect the structural changes that occur within a degenerating joint. The role of nutraceuticals in OA management can be defined only by an evidence-based approach to support their use. This paper reviews the clinical trials studying glucosamine, chondroitin sulfate, vitamin C, vitamin E, and avocado-soybean unsaponifiables. It highlights the need for additional randomized, placebo-controlled trials to further define the utility of nutraceuticals in OA treatment.
骨关节炎（OA）的治疗因处方药无法改变疾病转归而受到限制。因此，骨关节炎患者常服用一类称为营养保健品的食物物质，试图影响退变关节内发生的结构变化。营养保健品在骨关节炎管理中的作用只能通过支持其使用的循证方法来界定。本文综述了关于氨基葡萄糖、硫酸软骨素、维生素C、维生素E以及鳄梨大豆不皂化物的临床试验。强调需要更多随机、安慰剂对照试验，以进一步明确营养保健品在骨关节炎治疗中的效用。
